ACT26_DICDI
ID ACT26_DICDI Reviewed; 375 AA.
AC Q55CU2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Putative actin-26;
GN Name=act26; ORFNames=DDB_G0269902;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC various types of cell motility and are ubiquitously expressed in all
CC eukaryotic cells. Multiple isoforms are involved in various cellular
CC functions such as cytoskeleton structure, cell mobility, chromosome
CC movement and muscle contraction (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72301.1; -; Genomic_DNA.
DR RefSeq; XP_646389.1; XM_641297.1.
DR AlphaFoldDB; Q55CU2; -.
DR SMR; Q55CU2; -.
DR STRING; 44689.DDB0220464; -.
DR PaxDb; Q55CU2; -.
DR EnsemblProtists; EAL72301; EAL72301; DDB_G0269902.
DR GeneID; 8617344; -.
DR KEGG; ddi:DDB_G0269902; -.
DR dictyBase; DDB_G0269902; act26.
DR eggNOG; KOG0676; Eukaryota.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q55CU2; -.
DR PhylomeDB; Q55CU2; -.
DR Reactome; R-DDI-114608; Platelet degranulation.
DR Reactome; R-DDI-196025; Formation of annular gap junctions.
DR Reactome; R-DDI-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-DDI-5626467; RHO GTPases activate IQGAPs.
DR Reactome; R-DDI-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DDI-9013418; RHOBTB2 GTPase cycle.
DR PRO; PR:Q55CU2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017022; F:myosin binding; ISS:dictyBase.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:dictyBase.
DR GO; GO:0006909; P:phagocytosis; ISS:dictyBase.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00406; ACTINS_1; 1.
DR PROSITE; PS00432; ACTINS_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..375
FT /note="Putative actin-26"
FT /id="PRO_0000312676"
SQ SEQUENCE 375 AA; 42340 MW; 3076C3D315EDF2C8 CRC64;
MEDNITSIVI DCGSGMCKAG IGGEEFPRVS FPSIVGKPRF EKTMCAIGNK EYYVGDEAQS
QRGMLSLKYP IKNGIVVNWE YMEKLLFHMF YNELRVSPDQ YPILFTESPL NPKSNREMLT
QIMFEKFNVP ALYIAIQAVL SLYASGRTCG IVLDSGDDVT HTVPIYGGYV LQHSIIRLNF
AGSDLTEYMA KLLLERGYSF TTTSEMEIVK SIKEKLAYVA INFNAEMSKP IDTLETTYQL
PDGQIIIIGN ERFRCAEALF QPSMIGLECD GIHETIFKSI MMCDIDIRKH MYANILLSGG
NTMLSGISDR IYNQLRELAP NNMKILIVAS PERKNLVWIG GSILTTLPLF QEMWISKEEY
DEHGPSIINK KVGLY