DAND5_HUMAN
ID DAND5_HUMAN Reviewed; 189 AA.
AC Q8N907;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=DAN domain family member 5;
DE AltName: Full=Cerberus-like protein 2;
DE Short=Cerl-2;
DE AltName: Full=Cysteine knot superfamily 1, BMP antagonist 3;
DE AltName: Full=Gremlin-3;
DE Flags: Precursor;
GN Name=DAND5; Synonyms=CER2, CKTSF1B3, GREM3, SP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Itoh N.;
RT "Cysteine knot protein (SP1).";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=15254711;
RA Katoh M., Katoh M.;
RT "Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes
RT in silico.";
RL Oncol. Rep. 12:423-427(2004).
CC -!- FUNCTION: Seems to play a role in the correct specification of the
CC left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-
CC containing proteins play important roles during development,
CC organogenesis, tissue growth and differentiation (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR EMBL; AB070695; BAC82440.1; -; mRNA.
DR EMBL; AK095926; BAC04651.1; -; mRNA.
DR EMBL; BC101800; AAI01801.1; -; mRNA.
DR EMBL; BC113476; AAI13477.1; -; mRNA.
DR CCDS; CCDS12291.1; -.
DR RefSeq; NP_689867.1; NM_152654.2.
DR AlphaFoldDB; Q8N907; -.
DR IntAct; Q8N907; 1.
DR STRING; 9606.ENSP00000323155; -.
DR DrugBank; DB01593; Zinc.
DR DrugBank; DB14487; Zinc acetate.
DR GlyGen; Q8N907; 1 site.
DR iPTMnet; Q8N907; -.
DR PhosphoSitePlus; Q8N907; -.
DR BioMuta; DAND5; -.
DR DMDM; 74729571; -.
DR MassIVE; Q8N907; -.
DR MaxQB; Q8N907; -.
DR PaxDb; Q8N907; -.
DR PeptideAtlas; Q8N907; -.
DR PRIDE; Q8N907; -.
DR ProteomicsDB; 72482; -.
DR Antibodypedia; 26335; 288 antibodies from 22 providers.
DR DNASU; 199699; -.
DR Ensembl; ENST00000317060.4; ENSP00000323155.1; ENSG00000179284.6.
DR GeneID; 199699; -.
DR KEGG; hsa:199699; -.
DR MANE-Select; ENST00000317060.4; ENSP00000323155.1; NM_152654.3; NP_689867.1.
DR UCSC; uc002mwc.2; human.
DR CTD; 199699; -.
DR DisGeNET; 199699; -.
DR GeneCards; DAND5; -.
DR HGNC; HGNC:26780; DAND5.
DR HPA; ENSG00000179284; Tissue enriched (heart).
DR MIM; 609068; gene.
DR neXtProt; NX_Q8N907; -.
DR OpenTargets; ENSG00000179284; -.
DR PharmGKB; PA134875268; -.
DR VEuPathDB; HostDB:ENSG00000179284; -.
DR eggNOG; ENOG502RZ3T; Eukaryota.
DR GeneTree; ENSGT00530000063926; -.
DR HOGENOM; CLU_122900_0_0_1; -.
DR InParanoid; Q8N907; -.
DR OMA; PVVLWCR; -.
DR OrthoDB; 1134947at2759; -.
DR PhylomeDB; Q8N907; -.
DR TreeFam; TF106445; -.
DR PathwayCommons; Q8N907; -.
DR Reactome; R-HSA-1181150; Signaling by NODAL.
DR Reactome; R-HSA-1433617; Regulation of signaling by NODAL.
DR SignaLink; Q8N907; -.
DR BioGRID-ORCS; 199699; 18 hits in 1068 CRISPR screens.
DR ChiTaRS; DAND5; human.
DR GenomeRNAi; 199699; -.
DR Pharos; Q8N907; Tbio.
DR PRO; PR:Q8N907; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N907; protein.
DR Bgee; ENSG00000179284; Expressed in buccal mucosa cell and 70 other tissues.
DR ExpressionAtlas; Q8N907; baseline and differential.
DR Genevisible; Q8N907; HS.
DR GO; GO:0005576; C:extracellular region; NAS:BHF-UCL.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016015; F:morphogen activity; ISS:BHF-UCL.
DR GO; GO:0003283; P:atrial septum development; ISS:BHF-UCL.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; ISS:BHF-UCL.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; ISS:BHF-UCL.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISS:BHF-UCL.
DR GO; GO:1900108; P:negative regulation of nodal signaling pathway; ISS:BHF-UCL.
DR GO; GO:1900176; P:negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; IBA:GO_Central.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:BHF-UCL.
DR GO; GO:0035582; P:sequestering of BMP in extracellular matrix; IBA:GO_Central.
DR GO; GO:0038101; P:sequestering of nodal from receptor via nodal binding; ISS:BHF-UCL.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IBA:GO_Central.
DR GO; GO:0003281; P:ventricular septum development; ISS:BHF-UCL.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273; PTHR15273; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..189
FT /note="DAN domain family member 5"
FT /id="PRO_0000311804"
FT DOMAIN 101..186
FT /note="CTCK"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..148
FT /evidence="ECO:0000250|UniProtKB:O60565"
FT DISULFID 115..162
FT /evidence="ECO:0000250|UniProtKB:O60565"
FT DISULFID 125..183
FT /evidence="ECO:0000250|UniProtKB:O60565"
FT DISULFID 129..185
FT /evidence="ECO:0000250|UniProtKB:O60565"
SQ SEQUENCE 189 AA; 20180 MW; DE97689CBE2F65A7 CRC64;
MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP LVPASALGSW
KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM CKAVPFVQVF SRPGCSAIRL
RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP ARKRWAPVVL WCLTGSSASR RRVKISTMLI
EGCHCSPKA
