DANR_DROME
ID DANR_DROME Reviewed; 419 AA.
AC Q9VBW9;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Protein distal antenna-related {ECO:0000303|PubMed:12571108};
GN Name=danr {ECO:0000312|EMBL:AAF56408.1, ECO:0000312|FlyBase:FBgn0039283};
GN ORFNames=CG13651;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF56408.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF56408.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL89925.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL89925.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND TISSUE
RP SPECIFICITY.
RX PubMed=12571108; DOI=10.1242/dev.00323;
RA Emerald B.S., Curtiss J., Mlodzik M., Cohen S.M.;
RT "Distal antenna and distal antenna related encode nuclear proteins
RT containing pipsqueak motifs involved in antenna development in
RT Drosophila.";
RL Development 130:1171-1180(2003).
RN [5] {ECO:0000305}
RP FUNCTION, SUBUNIT, INTERACTION WITH DAN; EY AND DAC, AND TISSUE
RP SPECIFICITY.
RX PubMed=17493605; DOI=10.1016/j.ydbio.2007.04.006;
RA Curtiss J., Burnett M., Mlodzik M.;
RT "distal antenna and distal antenna-related function in the retinal
RT determination network during eye development in Drosophila.";
RL Dev. Biol. 306:685-702(2007).
CC -!- FUNCTION: Probable transcription factor with a role in the retinal
CC determination (RD) network. Regulates ato expression and is required
CC for normal R8 induction and differentiation. Danr appears to repress
CC Dan expression, but Dan is required for Danr expression anterior to the
CC morphogenetic furrow (MF). Dan and Danr lie downstream of so and
CC require dac function for highest levels of expression. Contributes to
CC differentiation of antenna-specific characteristics; effector gene that
CC acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and
CC spineless (ss) genes to control differentiation of distal antennal
CC structures. {ECO:0000269|PubMed:12571108, ECO:0000269|PubMed:17493605}.
CC -!- SUBUNIT: Interacts with itself, dan, ey and dac to form a complex (or
CC complexes) containing the RD factors. {ECO:0000269|PubMed:17493605}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000269|PubMed:12571108}.
CC -!- TISSUE SPECIFICITY: Coexpressed with dan in the presumptive distal
CC antenna, but not in the leg imaginal disk. Both proteins are also
CC expressed in the brain and the eye region of the eye-antenna disk.
CC First detected in early L3 eye disks in cells surrounding the newly
CC initiated morphogenetic furrow. Highly expressed in evenly spaced
CC clusters of cells anterior to the furrow, lower levels within and
CC posterior to the furrow. {ECO:0000269|PubMed:12571108,
CC ECO:0000269|PubMed:17493605}.
CC -!- DISRUPTION PHENOTYPE: Flies exhibit partial transformation of antenna
CC toward leg identity. Ectopic expression causes partial transformation
CC of distal leg structure toward antennal identity.
CC {ECO:0000269|PubMed:12571108}.
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DR EMBL; AE014297; AAF56408.1; -; Genomic_DNA.
DR EMBL; AY084187; AAL89925.1; -; mRNA.
DR RefSeq; NP_651343.1; NM_143086.3.
DR AlphaFoldDB; Q9VBW9; -.
DR SMR; Q9VBW9; -.
DR BioGRID; 67940; 15.
DR IntAct; Q9VBW9; 4.
DR STRING; 7227.FBpp0084155; -.
DR PaxDb; Q9VBW9; -.
DR PRIDE; Q9VBW9; -.
DR DNASU; 43020; -.
DR EnsemblMetazoa; FBtr0084780; FBpp0084155; FBgn0039283.
DR GeneID; 43020; -.
DR KEGG; dme:Dmel_CG13651; -.
DR UCSC; CG13651-RA; d. melanogaster.
DR CTD; 43020; -.
DR FlyBase; FBgn0039283; danr.
DR VEuPathDB; VectorBase:FBgn0039283; -.
DR eggNOG; ENOG502S5K1; Eukaryota.
DR GeneTree; ENSGT00530000068878; -.
DR HOGENOM; CLU_655994_0_0_1; -.
DR InParanoid; Q9VBW9; -.
DR OMA; KNWAKDP; -.
DR OrthoDB; 1534815at2759; -.
DR PhylomeDB; Q9VBW9; -.
DR SignaLink; Q9VBW9; -.
DR BioGRID-ORCS; 43020; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43020; -.
DR PRO; PR:Q9VBW9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039283; Expressed in eye disc (Drosophila) and 38 other tissues.
DR Genevisible; Q9VBW9; DM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:UniProtKB.
DR GO; GO:0007469; P:antennal development; IMP:UniProtKB.
DR GO; GO:0021556; P:central nervous system formation; IMP:FlyBase.
DR GO; GO:0048749; P:compound eye development; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0007379; P:segment specification; IMP:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..419
FT /note="Protein distal antenna-related"
FT /id="PRO_0000351202"
FT DOMAIN 15..66
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 42..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 333..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 45273 MW; F266E73DBDE9FE6A CRC64;
MDISAYQHMN IRMSTRGKRP LRNLTPNDKV RAIQRIHNGE TKASVSRDIG VPESTLRGWC
KNEQKLRFMC RQLGPDHLGL DTPPEKRAKF ELQLQLPPKF VALPPNYEEL GFGALPYSPA
DYPVQNESLL EKLSLVEFVK KNGGLHPEGA LHPGQAGVMD YSNNMLHQLN LLALLNSKLT
PQTADVLVDA QPKSEDNKVI DSPAASEDYS KNNYPLLSVK NWAKDPAKRV NSANQPEQVN
DKNNNALEAN SSAPQALVTE QAKTPMFSDT TMPLLPAPFP NPADLAPVIA PVTPANAPPT
GTDNQGAALL DWCKLFNASL NFLAFAAAAA SMQPGGGGPG GPSYNPNQMA SGGSEPDLET
YPFNEALLKR LSPLAHSEAS NESYCDSEPE DLSVRSCASK ASSRSHTPDK SVGSSDAEQ
