ID   ACT27_DICDI             Reviewed;         372 AA.
AC   Q54HE9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Putative actin-27;
GN   Name=act27; ORFNames=DDB_G0289533;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells. Multiple isoforms are involved in various cellular
CC       functions such as cytoskeleton structure, cell mobility, chromosome
CC       movement and muscle contraction (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; AAFI02000141; EAL62698.2; -; Genomic_DNA.
DR   RefSeq; XP_636189.2; XM_631097.2.
DR   AlphaFoldDB; Q54HE9; -.
DR   SMR; Q54HE9; -.
DR   STRING; 44689.DDB0229353; -.
DR   PaxDb; Q54HE9; -.
DR   EnsemblProtists; EAL62698; EAL62698; DDB_G0289533.
DR   GeneID; 8627176; -.
DR   KEGG; ddi:DDB_G0289533; -.
DR   dictyBase; DDB_G0289533; act27.
DR   eggNOG; KOG0676; Eukaryota.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; Q54HE9; -.
DR   PhylomeDB; Q54HE9; -.
DR   Reactome; R-DDI-114608; Platelet degranulation.
DR   Reactome; R-DDI-196025; Formation of annular gap junctions.
DR   Reactome; R-DDI-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-DDI-5626467; RHO GTPases activate IQGAPs.
DR   Reactome; R-DDI-5663213; RHO GTPases Activate WASPs and WAVEs.
DR   Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR   Reactome; R-DDI-9013418; RHOBTB2 GTPase cycle.
DR   PRO; PR:Q54HE9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0017022; F:myosin binding; ISS:dictyBase.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:dictyBase.
DR   GO; GO:0006909; P:phagocytosis; ISS:dictyBase.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..372
FT                   /note="Putative actin-27"
FT                   /id="PRO_0000312677"
SQ   SEQUENCE   372 AA;  41545 MW;  C446A60C29461FBB CRC64;
     MEINVQAIVI DNGSDTCKAG FVGEEAPHSE FPSIVGIDQN DSYVGNEAQS KRGILTLKYP
     IERGIITNWD DMEKIWHHAF YNELGVAPEE NIVVLSESPL NPEENREKMA QIMFETFKTP
     AIYVENQAVF SIYNSGRMTG IVLDSGDSAS HVVPVYEGLA LPHATSSLGF AGCDLTDQMS
     LLLNDLGYNL EREIVRDIKE KLSYVSSDFS WEINDPSTLG KSYELPDGQV ITIDKELFAC
     PEVLFLPYAF FGTNLDGIDK AIYNSIMKCN DDIHNDLYGN VVLSGGSTMF PGIEYRMYKG
     LTQLAPSTTE IVINAEPDRK NSVWIGGSIL GLVPNFQELC IDKEDYDEYG PSFVNLVKSF
     REQNHQNYYG EN