ID   DANR_DROPS              Reviewed;         432 AA.
AC   Q29CW0;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Protein distal antenna-related {ECO:0000250|UniProtKB:Q9VBW9};
GN   Name=danr {ECO:0000250|UniProtKB:Q9VBW9}; ORFNames=GA12437;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Probable transcription factor with a role in the retinal
CC       determination (RD) network. Regulates ato expression and is required
CC       for normal R8 induction and differentiation. Danr appears to repress
CC       Dan expression, but Dan is required for Danr expression anterior to the
CC       morphogenetic furrow (MF). Dan and Danr lie downstream of so and
CC       require dac function for highest levels of expression. Contributes to
CC       differentiation of antenna-specific characteristics; effector gene that
CC       acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and
CC       spineless (ss) genes to control differentiation of distal antennal
CC       structures (By similarity). {ECO:0000250|UniProtKB:Q9VBW9}.
CC   -!- SUBUNIT: Interacts with itself, dan, ey and dac to form a complex (or
CC       complexes) containing the RD factors. {ECO:0000250|UniProtKB:Q9VBW9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VBW9,
CC       ECO:0000255|PROSITE-ProRule:PRU00320}.
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DR   EMBL; CH475399; EAL29349.2; -; Genomic_DNA.
DR   RefSeq; XP_001352380.2; XM_001352344.3.
DR   AlphaFoldDB; Q29CW0; -.
DR   SMR; Q29CW0; -.
DR   STRING; 7237.FBpp0285372; -.
DR   EnsemblMetazoa; FBtr0286934; FBpp0285372; FBgn0072483.
DR   GeneID; 4811819; -.
DR   KEGG; dpo:Dpse_GA12437; -.
DR   eggNOG; ENOG502S5K1; Eukaryota.
DR   HOGENOM; CLU_655994_0_0_1; -.
DR   InParanoid; Q29CW0; -.
DR   OMA; KNWAKDP; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0072483; Expressed in insect adult head and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0007469; P:antennal development; ISS:UniProtKB.
DR   GO; GO:0021556; P:central nervous system formation; IEA:EnsemblMetazoa.
DR   GO; GO:0048749; P:compound eye development; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007379; P:segment specification; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR007889; HTH_Psq.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..432
FT                   /note="Protein distal antenna-related"
FT                   /id="PRO_0000351203"
FT   DOMAIN          15..66
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DNA_BIND        42..62
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   REGION          195..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  47253 MW;  6684115AE34A2FBE CRC64;
     MDISAYQHMN IRMSTRGKRP LRNLTPNDKV RAIQRIHNGE TKASVSRDLG VPESTLRGWC
     KNEQKLRFMC RQLGPDHLGI DTHTPPEKRA KFDLQLLPPK LATLPNYDDL GLSNFLFSAT
     EFPTQKESLF EKLSLVEFVK KNGLHPSAIR ELGDTHSLNA AANAVSGVDY STNNMINQLT
     LLAQLNSKLS YQMGESADTD IKSPQSTTDI TDTAREENST KTSCPLLTVK NWAKDPAKRA
     HFNQATQLNP NNDKNNNAVD PSYSNLTTMK YPLIMEPVKS IYPETTVSAI PPPPFSTYSD
     LASAASAPTT DNDCQGAALL DWCKLFNASL NFLAFAAAAA SMQPAGGTIP KSTATQLPAT
     EADETYPFNN NLVKRLSPLA HSDASNESYF DSEPEDLSVR SCASVSSRNN SRSQTPDKST
     ATSIACLSDG EQ