DAN_AEDAE
ID DAN_AEDAE Reviewed; 675 AA.
AC Q16IB4;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Protein distal antenna {ECO:0000250|UniProtKB:Q29CW2};
GN Name=dan {ECO:0000250|UniProtKB:Q29CW2}; ORFNames=AAEL013733;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT34003.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Probable transcription factor with a role in the retinal
CC determination (RD) network. Contributes to differentiation of antenna-
CC specific characteristics (By similarity).
CC {ECO:0000250|UniProtKB:Q29CW2}.
CC -!- SUBUNIT: Homomers. Interacts with itself, danr, ey and dac to form a
CC complex (or complexes) containing the RD factors (By similarity).
CC {ECO:0000250|UniProtKB:Q29CW2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q29CW2,
CC ECO:0000255|PROSITE-ProRule:PRU00320}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAT34003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH478090; EAT34003.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001663918.1; XM_001663868.1.
DR AlphaFoldDB; Q16IB4; -.
DR SMR; Q16IB4; -.
DR STRING; 7159.AAEL013733-PA; -.
DR PRIDE; Q16IB4; -.
DR VEuPathDB; VectorBase:AAEL013733; -.
DR eggNOG; ENOG502S5K1; Eukaryota.
DR HOGENOM; CLU_405596_0_0_1; -.
DR InParanoid; Q16IB4; -.
DR OrthoDB; 1534815at2759; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0007469; P:antennal development; ISS:UniProtKB.
DR GO; GO:0048749; P:compound eye development; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007379; P:segment specification; ISS:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..675
FT /note="Protein distal antenna"
FT /id="PRO_0000351198"
FT DOMAIN 5..56
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 32..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 239..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..386
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 73178 MW; D3ED99534B2A8E68 CRC64;
MMMATKGKRP LRHLTATDKI DAIQRIHDGE SKASVARDIG VPESTLRGWC KNEEKLRYMS
RQSAENAEKL TNEATAAALT AVAAAELFNG PPEKRLKLEQ GLFGNGKLKY DDSFYKSPRG
PMNGLDLSGG DKGLGVSGGD IIMNGLHGAD FSSKSKEMNL KGYGADLSKH GDPKQADLSM
AAISPLTSLS HLSGMSGLAQ SPLALSFNEI ATNLNLFAQL NNNHNLATMS NLGGLSAAQS
LRNARPKANT SQSPRTSNLS DVNGDKNPSL TVRNLAKLQQ KNSGDLSNGM MHGINLSDKY
KQQPSAAPLG RDTNAPVDEA LWYWLKSQQA MLGLNNLYSS MPRPSSPQQS SSPPQQHQQV
QHHPSTQTPT PPIVSTPQPT PPSSAPSLTP EDTKNSSWFW QWYKTFGASL MPGDKSNNNT
INANANSKQA AYENILYSQL TKGQNSDSLN NNAQPINLNI ISSNGPENVK SEPEDLSNHN
HSSSNAAAVA APAEDLQRFN PSPSTSAKSE LKQEDDEEQA GPADDESPME SKCNGKVKDV
LDNFLFQNPS SNDRASPANL SIRSNNSPRR RSVSPAVSNH HVNSPEPENG DLAHKSDISE
DSNHMLVADI KSSAEAVEHG EKFLKWLEAC SDPNVTAMQV MQFKYLLNSI KLSAERQQQN
AVSSGEERTR VRRRK
