DAN_CULQU
ID DAN_CULQU Reviewed; 662 AA.
AC B0X560;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Protein distal antenna {ECO:0000250|UniProtKB:Q29CW2};
GN Name=dan {ECO:0000250|UniProtKB:Q29CW2}; ORFNames=CPIJ014460;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000312|EMBL:EDS40706.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000312|EMBL:EDS40706.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transcription factor with a role in the retinal
CC determination (RD) network. Contributes to differentiation of antenna-
CC specific characteristics (By similarity).
CC {ECO:0000250|UniProtKB:Q29CW2}.
CC -!- SUBUNIT: Homomers. Interacts with itself, danr, ey and dac to form a
CC complex (or complexes) containing the RD factors (By similarity).
CC {ECO:0000250|UniProtKB:Q29CW2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q29CW2,
CC ECO:0000255|PROSITE-ProRule:PRU00320}.
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DR EMBL; DS232365; EDS40706.1; -; Genomic_DNA.
DR RefSeq; XP_001864782.1; XM_001864747.1.
DR AlphaFoldDB; B0X560; -.
DR SMR; B0X560; -.
DR STRING; 7176.CPIJ014460-PA; -.
DR GeneID; 6047768; -.
DR KEGG; cqu:CpipJ_CPIJ014460; -.
DR VEuPathDB; VectorBase:CPIJ014460; -.
DR VEuPathDB; VectorBase:CQUJHB016679; -.
DR eggNOG; ENOG502S5K1; Eukaryota.
DR HOGENOM; CLU_405596_0_0_1; -.
DR InParanoid; B0X560; -.
DR OMA; HMNIRMG; -.
DR OrthoDB; 1534815at2759; -.
DR PhylomeDB; B0X560; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0007469; P:antennal development; ISS:UniProtKB.
DR GO; GO:0048749; P:compound eye development; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007379; P:segment specification; ISS:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..662
FT /note="Protein distal antenna"
FT /id="PRO_0000351199"
FT DOMAIN 21..72
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 48..68
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 265..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..400
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 70822 MW; 63ED5E68B5E17AAD CRC64;
MPMSSSGYSR TTTHFKMMMA TKGKRPLRHL TATDKIDAIQ RIHDGESKAS VARDIGVPES
TLRGWCKNEE KLRYMSRQSA ENADKLTSEA TAAALTAVAA AELFNGPPEK RMKLEQGLFG
KKYDESFYKS PRGMNGLDLS GGGDKGLGVS GGDIIMNGLH GADFSAFAKT AAEISAMGKA
KDRYGADLSR NGGGDPGKAE LSMAAISPLT SLSHLSGMGG LAQSPLALSF NEIATNLNLI
AQLNNNHNLA TMSNLGGLTA AQSLRNARPK GNASQSPRAS LPDSSGSGGG TPGDKSTPSL
TVRNLAKLQQ KTSSELQNNG RDPNAPVDEA LWYWLKSQQA MLGLNNLYSQ MPRPSSPQQP
QSTPPTTTTT QQQQPQSSTP PTATPPIVST PQPTPPSSAP SLTPEDTKNS SWFWQWYKTF
GASLMPGDKS CNNNSINATN ANNSKYENIL YSQLTKGQSP PTTADSLNNN AQPINLNISS
NGVVDHLKSE PEDLTTTTNP SMLPPEDHTR FNPSPSTSIK SELKPEVDED EDEDDEVAKC
NGANTAVKQV LDNLLYSQSS PGPVATAPSP LSPSSSTHEN GHATPTPLAD DLKSTCSEDT
DLKSSAEAVE HGEKFLKWLE ACSDPNVTAM QVMQFKYLLN SIKLSAERQN GGGEERTRRR
RK
