DAN_DROPS
ID DAN_DROPS Reviewed; 683 AA.
AC Q29CW2;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Protein distal antenna {ECO:0000250|UniProtKB:Q9VBW6};
GN Name=dan {ECO:0000250|UniProtKB:Q9VBW6}; ORFNames=GA11234;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Probable transcription factor with a role in the retinal
CC determination (RD) network. Regulates ato expression and is required
CC for normal R8 induction and differentiation. Danr appears to repress
CC Dan expression, but Dan is required for Danr expression anterior to the
CC morphogenetic furrow (MF). Dan and Danr lie downstream of so and
CC require dac function for highest levels of expression. Contributes to
CC differentiation of antenna-specific characteristics; effector gene that
CC acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and
CC spineless (ss) genes to control differentiation of distal antennal
CC structures (By similarity). {ECO:0000250|UniProtKB:Q9VBW6}.
CC -!- SUBUNIT: Homomers. Interacts with itself, danr, ey and dac to form a
CC complex (or complexes) containing the RD factors (By similarity).
CC {ECO:0000250|UniProtKB:Q9VBW6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VBW6,
CC ECO:0000255|PROSITE-ProRule:PRU00320}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH475399; EAL29347.2; -; Genomic_DNA.
DR AlphaFoldDB; Q29CW2; -.
DR SMR; Q29CW2; -.
DR STRING; 7237.FBpp0285373; -.
DR eggNOG; ENOG502S5K1; Eukaryota.
DR HOGENOM; CLU_405596_0_0_1; -.
DR InParanoid; Q29CW2; -.
DR OMA; HMNIRMG; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0007469; P:antennal development; ISS:UniProtKB.
DR GO; GO:0048749; P:compound eye development; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007379; P:segment specification; ISS:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..683
FT /note="Protein distal antenna"
FT /id="PRO_0000351201"
FT DOMAIN 7..58
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 34..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 220..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 74283 MW; F6E81F32289360BC CRC64;
MNIRMGTKGK RPLRSLTPRD KIHAIQRIHD GESKASVARD IGVPESTLRG WCKNEDKLRF
MSRQSTTDKM CADALADKLD VSTGLLGPPE KRQRIDPSLP LNFSNKMKFD ELGFKRAPLN
GLDYSTNKNI SELNYNGLAV DYVGFNGQHK VFSGDINRPA NPSPNAISPL SSLTHLSGLT
GLSQSPLAIS FNELTTNLNL LAQLNPSLAA MSGLNSFPTT ANNLRNSKPS VQPPLQVQSP
RSDSGDRTPG LSVKNWAKQK PLSAVSSDVS CSINLTIKNE AKGGDIKSPS PSIAPSHVGS
IISLSNLAED PLLYWLKSQQ TMLGLNSLYP PMGMTSPPIR SSTPQHIIQH AQTPPLPSAP
LTPSSTPSGS LDEKNVAWYN WCKVFGASLN TLNPNSATLA ALQANSLQHQ HQPISAVSDG
TDIADTSKGP FDNILYSHLT KESETPSVRS LSSNEHNQLD QIEGDEVTDP DLDAEIEGDV
PGKPEDLSAS AKRITPSQSP IASLVPESHT TEPCAKTSTT PSDCISRPGS VGGDCKKILD
NMLYKIGGIK SHMPTIVDTA CESEASFINE HNQHSNNNDI SASNNNNNNS NKTDEEEKAK
YLDLTGDNED VKAIRHGEKF LQWLENCSNP RVTAVQLMQL RFLIAAIKSS NEPQVTEKPN
KDLLENEENT EEDSCRNKIR RRK
