ID   DAO4_CAEEL              Reviewed;         217 AA.
AC   Q23262;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein dao-4 {ECO:0000305};
DE   AltName: Full=Dauer or aging adult overexpression 4 {ECO:0000312|WormBase:ZC373.6};
DE   Flags: Precursor;
GN   Name=dao-4 {ECO:0000312|WormBase:ZC373.6};
GN   ORFNames=ZC373.6 {ECO:0000312|WormBase:ZC373.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=24569038; DOI=10.1534/g3.113.009522;
RA   Jackson B.M., Abete-Luzi P., Krause M.W., Eisenmann D.M.;
RT   "Use of an activated beta-catenin to identify Wnt pathway target genes in
RT   caenorhabditis elegans, including a subset of collagen genes expressed in
RT   late larval development.";
RL   G3 (Bethesda) 4:733-747(2014).
CC   -!- FUNCTION: Probably acts downstream of the Wnt signaling pathway.
CC       {ECO:0000269|PubMed:24569038}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24569038}. Secreted
CC       {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the seam cells, and in the hyp7
CC       syncytial hypodermis in the mid-L4 larval stage (PubMed:24569038). Not
CC       expressed in the cells of the developing vulva (PubMed:24569038).
CC       {ECO:0000269|PubMed:24569038}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes dumpy body shape
CC       (PubMed:24569038). Defects in cuticle integrity (PubMed:24569038).
CC       {ECO:0000269|PubMed:24569038}.
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DR   EMBL; BX284606; CAA88978.1; -; Genomic_DNA.
DR   PIR; T27524; T27524.
DR   RefSeq; NP_509691.1; NM_077290.5.
DR   AlphaFoldDB; Q23262; -.
DR   STRING; 6239.ZC373.6; -.
DR   EPD; Q23262; -.
DR   PaxDb; Q23262; -.
DR   PeptideAtlas; Q23262; -.
DR   EnsemblMetazoa; ZC373.6.1; ZC373.6.1; WBGene00000930.
DR   GeneID; 191146; -.
DR   KEGG; cel:CELE_ZC373.6; -.
DR   UCSC; ZC373.6; c. elegans.
DR   CTD; 191146; -.
DR   WormBase; ZC373.6; CE02379; WBGene00000930; dao-4.
DR   eggNOG; ENOG502TH6U; Eukaryota.
DR   HOGENOM; CLU_1278637_0_0_1; -.
DR   InParanoid; Q23262; -.
DR   OMA; NVNWHSY; -.
DR   OrthoDB; 1428220at2759; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000930; Expressed in larva and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..217
FT                   /note="Protein dao-4"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004201494"
SQ   SEQUENCE   217 AA;  24193 MW;  D6B4DC27D56D73EA CRC64;
     MKIALYSILL ITVCYLSSTD AYLFDPKAVD ALLREIRARL QATGKEPHAR KIEQETEEIK
     KEELMQAEDV EGSGSGEEIE GSGEVISTIT GVPIMDNEEK KDLKPENFPR PEPIFDKYGN
     LKSKDKLEAL TYSNFKKQAP ATLQDHYNLN PTGTLQMLQG LDIHGGSGGY HRALSGGYLP
     PSTYDPYNVN WHSYGDEGVK MKDKAISVFR RVIAPGR