ID   DAP1_BOVIN              Reviewed;         102 AA.
AC   Q5EAE6; Q3SYY4;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Death-associated protein 1;
DE            Short=DAP-1;
GN   Name=DAP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of autophagy. Involved in mediating
CC       interferon-gamma-induced cell death (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive
CC       activity of DAP toward autophagy (By similarity). {ECO:0000250}.
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DR   EMBL; BT020623; AAX08640.1; -; mRNA.
DR   EMBL; BC103332; AAI03333.1; -; mRNA.
DR   RefSeq; NP_001071526.1; NM_001078058.2.
DR   AlphaFoldDB; Q5EAE6; -.
DR   STRING; 9913.ENSBTAP00000008327; -.
DR   PaxDb; Q5EAE6; -.
DR   PRIDE; Q5EAE6; -.
DR   Ensembl; ENSBTAT00000008327; ENSBTAP00000008327; ENSBTAG00000006346.
DR   GeneID; 616066; -.
DR   KEGG; bta:616066; -.
DR   CTD; 1611; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006346; -.
DR   VGNC; VGNC:50122; DAP.
DR   eggNOG; ENOG502S4ST; Eukaryota.
DR   GeneTree; ENSGT00940000154574; -.
DR   HOGENOM; CLU_150759_2_0_1; -.
DR   InParanoid; Q5EAE6; -.
DR   OMA; PTHDARP; -.
DR   OrthoDB; 1620337at2759; -.
DR   TreeFam; TF329716; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000006346; Expressed in saliva-secreting gland and 106 other tissues.
DR   GO; GO:0070513; F:death domain binding; IBA:GO_Central.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   InterPro; IPR024130; DAP1/DAPL1.
DR   PANTHER; PTHR13177; PTHR13177; 1.
DR   Pfam; PF15228; DAP; 1.
PE   3: Inferred from homology;
KW   Acetylation; Apoptosis; Autophagy; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P51397"
FT   CHAIN           2..102
FT                   /note="Death-associated protein 1"
FT                   /id="PRO_0000239991"
FT   REGION          1..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51397"
FT   MOD_RES         3
FT                   /note="Phosphoserine; by MTOR"
FT                   /evidence="ECO:0000250|UniProtKB:P51397"
FT   MOD_RES         29
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91XC8"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51397"
FT   MOD_RES         51
FT                   /note="Phosphoserine; by MTOR"
FT                   /evidence="ECO:0000250|UniProtKB:P51397"
FT   MOD_RES         91
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51397"
FT   CONFLICT        36..37
FT                   /note="TR -> AK (in Ref. 1; AAX08640)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        62
FT                   /note="V -> A (in Ref. 1; AAX08640)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="R -> K (in Ref. 1; AAX08640)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="S -> C (in Ref. 1; AAX08640)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   102 AA;  11189 MW;  535CD3E22D9E2302 CRC64;
     MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHSGDTREEK DKDDQEWESP SPPKPTVFIS
     GVIARGDKDF PPAAAQVAHQ KPHASIDRHP SPRTQHIQQP RK