ID   DAPAL_HALS3             Reviewed;         304 AA.
AC   B0R3D6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Uncharacterized DapA-like lyase OE_1665R;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=OE_1665R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM774415; CAP13250.1; -; Genomic_DNA.
DR   RefSeq; WP_012289156.1; NC_010364.1.
DR   AlphaFoldDB; B0R3D6; -.
DR   SMR; B0R3D6; -.
DR   EnsemblBacteria; CAP13250; CAP13250; OE_1665R.
DR   GeneID; 5953800; -.
DR   KEGG; hsl:OE_1665R; -.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   OMA; LPPMRYK; -.
DR   PhylomeDB; B0R3D6; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   PROSITE; PS00666; DHDPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Schiff base.
FT   CHAIN           1..304
FT                   /note="Uncharacterized DapA-like lyase OE_1665R"
FT                   /id="PRO_1000124038"
FT   ACT_SITE        58
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        121
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        147
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        175
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   304 AA;  31397 MW;  B1AF88266E5116FC CRC64;
     MPTHAPAPGS GDPLGLHGVV PPVVTAFDAD ESLDADTTAD HARMVVDAGV HGVFPLGTNG
     EFPLLTPSER DRVVTAVVDE VGGEVPVIAG VGAPSTRQTV AHAEHAASVG ADGVVVVTPF
     YYPLDGTAAV EHYRRVAAAV DCPVYVYHIP SKTGNELSLE TLAALAEIDT LAGVKDSSKD
     VPWLGQAVDA HPELTFLAGS DSLLAPGLDV GCAGLVSAVA NVAPELVVGL YEAYDEGDRE
     RARARQSTVY EVRAALKRGP YMAGVKAALG LRGFDAGPLR SPLRGLDDDD RAALEADLAD
     LGLL