ID   DAPAL_HALSA             Reviewed;         304 AA.
AC   Q9HS19;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Uncharacterized DapA-like lyase VNG_0444G;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=VNG_0444G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AE004437; AAG18989.1; -; Genomic_DNA.
DR   PIR; A84203; A84203.
DR   RefSeq; WP_012289156.1; NC_002607.1.
DR   AlphaFoldDB; Q9HS19; -.
DR   SMR; Q9HS19; -.
DR   STRING; 64091.VNG_0444G; -.
DR   PaxDb; Q9HS19; -.
DR   EnsemblBacteria; AAG18989; AAG18989; VNG_0444G.
DR   GeneID; 5953800; -.
DR   KEGG; hal:VNG_0444G; -.
DR   PATRIC; fig|64091.14.peg.333; -.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   InParanoid; Q9HS19; -.
DR   OrthoDB; 65776at2157; -.
DR   PhylomeDB; Q9HS19; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   PROSITE; PS00666; DHDPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Reference proteome; Schiff base.
FT   CHAIN           1..304
FT                   /note="Uncharacterized DapA-like lyase VNG_0444G"
FT                   /id="PRO_0000103195"
FT   ACT_SITE        58
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        121
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        147
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        175
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   304 AA;  31397 MW;  B1AF88266E5116FC CRC64;
     MPTHAPAPGS GDPLGLHGVV PPVVTAFDAD ESLDADTTAD HARMVVDAGV HGVFPLGTNG
     EFPLLTPSER DRVVTAVVDE VGGEVPVIAG VGAPSTRQTV AHAEHAASVG ADGVVVVTPF
     YYPLDGTAAV EHYRRVAAAV DCPVYVYHIP SKTGNELSLE TLAALAEIDT LAGVKDSSKD
     VPWLGQAVDA HPELTFLAGS DSLLAPGLDV GCAGLVSAVA NVAPELVVGL YEAYDEGDRE
     RARARQSTVY EVRAALKRGP YMAGVKAALG LRGFDAGPLR SPLRGLDDDD RAALEADLAD
     LGLL