DAPAL_PYRAB
ID DAPAL_PYRAB Reviewed; 294 AA.
AC Q9UZ94; G8ZKQ4;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Uncharacterized DapA-like lyase PYRAB12600;
DE EC=4.-.-.-;
GN Name=dapAL; Synonyms=dapA; OrderedLocusNames=PYRAB12600; ORFNames=PAB0832;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR EMBL; AJ248287; CAB50165.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE70697.1; -; Genomic_DNA.
DR PIR; H75033; H75033.
DR RefSeq; WP_010868373.1; NC_000868.1.
DR AlphaFoldDB; Q9UZ94; -.
DR SMR; Q9UZ94; -.
DR STRING; 272844.PAB0832; -.
DR EnsemblBacteria; CAB50165; CAB50165; PAB0832.
DR GeneID; 1496643; -.
DR KEGG; pab:PAB0832; -.
DR PATRIC; fig|272844.11.peg.1340; -.
DR eggNOG; arCOG04172; Archaea.
DR HOGENOM; CLU_049343_5_1_2; -.
DR OMA; YYGYGGF; -.
DR OrthoDB; 65776at2157; -.
DR PhylomeDB; Q9UZ94; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR PANTHER; PTHR12128; PTHR12128; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR PROSITE; PS00666; DHDPS_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Lyase; Schiff base.
FT CHAIN 1..294
FT /note="Uncharacterized DapA-like lyase PYRAB12600"
FT /id="PRO_0000103203"
FT ACT_SITE 43
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 104
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 130
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 158
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 294 AA; 32913 MW; 7FA3D40BF9E9FAC2 CRC64;
MEGVIVPLVT PFREDYSIDF EALEWHIRFL EEKGVHGIFV NSTTGEFTSL NTDERKMLAE
KGREITSGMY LVGTGSTSTL EVIELSRHAE DIGADGIVIV APYYCKLKDE EILKHFSMVA
ERVDIPIIVY AIPSCANPVP VDIIRKVSLE YSNIIGVKAS VDSLTYLQEL IEVKEERKDF
RVFTGLDQYF LSTLLLGGDG GIMACANFAP EIHLQIWNSF KRRNFEEAIK LSRVLGEISR
IYNVASSFAS AVKLAMIAKG FPIKPVLRPP HVIDGEEVFN EIKGILRSLE NVKP