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DAPAL_PYRAB
ID   DAPAL_PYRAB             Reviewed;         294 AA.
AC   Q9UZ94; G8ZKQ4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Uncharacterized DapA-like lyase PYRAB12600;
DE            EC=4.-.-.-;
GN   Name=dapAL; Synonyms=dapA; OrderedLocusNames=PYRAB12600; ORFNames=PAB0832;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AJ248287; CAB50165.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70697.1; -; Genomic_DNA.
DR   PIR; H75033; H75033.
DR   RefSeq; WP_010868373.1; NC_000868.1.
DR   AlphaFoldDB; Q9UZ94; -.
DR   SMR; Q9UZ94; -.
DR   STRING; 272844.PAB0832; -.
DR   EnsemblBacteria; CAB50165; CAB50165; PAB0832.
DR   GeneID; 1496643; -.
DR   KEGG; pab:PAB0832; -.
DR   PATRIC; fig|272844.11.peg.1340; -.
DR   eggNOG; arCOG04172; Archaea.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   OMA; YYGYGGF; -.
DR   OrthoDB; 65776at2157; -.
DR   PhylomeDB; Q9UZ94; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   PROSITE; PS00666; DHDPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Schiff base.
FT   CHAIN           1..294
FT                   /note="Uncharacterized DapA-like lyase PYRAB12600"
FT                   /id="PRO_0000103203"
FT   ACT_SITE        43
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        104
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        130
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        158
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   294 AA;  32913 MW;  7FA3D40BF9E9FAC2 CRC64;
     MEGVIVPLVT PFREDYSIDF EALEWHIRFL EEKGVHGIFV NSTTGEFTSL NTDERKMLAE
     KGREITSGMY LVGTGSTSTL EVIELSRHAE DIGADGIVIV APYYCKLKDE EILKHFSMVA
     ERVDIPIIVY AIPSCANPVP VDIIRKVSLE YSNIIGVKAS VDSLTYLQEL IEVKEERKDF
     RVFTGLDQYF LSTLLLGGDG GIMACANFAP EIHLQIWNSF KRRNFEEAIK LSRVLGEISR
     IYNVASSFAS AVKLAMIAKG FPIKPVLRPP HVIDGEEVFN EIKGILRSLE NVKP
 
 
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