ID   DAPAL_PYRAE             Reviewed;         301 AA.
AC   Q8ZU75;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Uncharacterized DapA-like lyase PAE2915;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=PAE2915;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AE009441; AAL64533.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZU75; -.
DR   SMR; Q8ZU75; -.
DR   STRING; 178306.PAE2915; -.
DR   EnsemblBacteria; AAL64533; AAL64533; PAE2915.
DR   KEGG; pai:PAE2915; -.
DR   PATRIC; fig|178306.9.peg.2180; -.
DR   eggNOG; arCOG04172; Archaea.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   InParanoid; Q8ZU75; -.
DR   OMA; GMDACVP; -.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Reference proteome; Schiff base.
FT   CHAIN           1..301
FT                   /note="Uncharacterized DapA-like lyase PAE2915"
FT                   /id="PRO_0000103202"
FT   ACT_SITE        44
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        107
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        133
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        162
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   301 AA;  32918 MW;  2D542BBBAC9623E9 CRC64;
     MKLEGVIVAT VMPFAKDGVN YEGLRLLLSK IVEAGYHGVF PTSSTGEVTK LSAEERVRVM
     QLAKEVAGGK ALVVAGTGTG DHVSTIDIAR KYKDVGVDAI LITPPYYIQY DWAALYAFYK
     KVLDKVDIPV ILYTIPLATG YNVPVEVFEM VAGEYSQVVG VKDSSGDFRY HLDLIHLLGK
     RLSVLQGLDM LFVPSLVMGA HGGILAGPNF LGRITLEQYL LVKEGKIAEA VALHNKLMPL
     WRFMGGCGLV GKLGGKWPTL YKLATQLVHG IDMGPPREPL PPVDDKDRRE LEKILKELGL
     I