ID   DAPAL_THEAC             Reviewed;         292 AA.
AC   Q9HJ17;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Uncharacterized DapA-like lyase Ta1157;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=Ta1157;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AL445066; CAC12282.1; -; Genomic_DNA.
DR   RefSeq; WP_010901564.1; NC_002578.1.
DR   AlphaFoldDB; Q9HJ17; -.
DR   SMR; Q9HJ17; -.
DR   STRING; 273075.Ta1157; -.
DR   DNASU; 1456657; -.
DR   EnsemblBacteria; CAC12282; CAC12282; CAC12282.
DR   GeneID; 1456657; -.
DR   KEGG; tac:Ta1157; -.
DR   eggNOG; arCOG04172; Archaea.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   OMA; GMDACVP; -.
DR   OrthoDB; 65776at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   PROSITE; PS00666; DHDPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Reference proteome; Schiff base.
FT   CHAIN           1..292
FT                   /note="Uncharacterized DapA-like lyase Ta1157"
FT                   /id="PRO_0000103207"
FT   ACT_SITE        44
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        106
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        132
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        161
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   292 AA;  33011 MW;  74A154212957A889 CRC64;
     MYKGIVTPMI TPMGQNGEID YRATEILIDN LADFGVDGLF PMGSTGLFPM FSTDEKKKFL
     GFVRDHSKKI EVYAGVGSSS TQESVELSKY TEDIGIKVRV LMPTYYIKPD EDWMYRHFST
     VISAASNDLF IYNIPQLSGS WISESLIEKL TREFSNVKGI KDSSGDMRFF SRIIRHKNEK
     FDIFQGQDDL LFLSLSIGAS GGVCGLSNIS PYITNLYHEF SAGNLEKARK IQIDEVNPLM
     YAINEATFPA GYYYAFYKMN GIKGGYRAPM VEPTTDQKKK IDQELTKIPK KQ