ID   DAPAL_THEKO             Reviewed;         292 AA.
AC   Q5JGK8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Uncharacterized DapA-like lyase TK1237;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=TK1237;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AP006878; BAD85426.1; -; Genomic_DNA.
DR   RefSeq; WP_011250188.1; NC_006624.1.
DR   AlphaFoldDB; Q5JGK8; -.
DR   SMR; Q5JGK8; -.
DR   STRING; 69014.TK1237; -.
DR   EnsemblBacteria; BAD85426; BAD85426; TK1237.
DR   GeneID; 3234305; -.
DR   KEGG; tko:TK1237; -.
DR   PATRIC; fig|69014.16.peg.1211; -.
DR   eggNOG; arCOG04172; Archaea.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   InParanoid; Q5JGK8; -.
DR   OMA; YYGYGGF; -.
DR   OrthoDB; 65776at2157; -.
DR   PhylomeDB; Q5JGK8; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   PROSITE; PS00666; DHDPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Reference proteome; Schiff base.
FT   CHAIN           1..292
FT                   /note="Uncharacterized DapA-like lyase TK1237"
FT                   /id="PRO_0000103206"
FT   ACT_SITE        43
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        105
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        131
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        159
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   292 AA;  32762 MW;  5AC7397E1F72E6B8 CRC64;
     MRGVIVPIVT PFKEDYSIDV PALEEHLDYL QKVGVHGIFI NATTGEFTSL SKEERRFLAE
     KGRELVTSAF YLVGTASSNT LEVIELTKHA QDIGADYAVI APPYYCPLTE EALFRHYSMI
     AEKTDIPIIL YNIPACANSL SVPLVKRLTI EYPSIAGIKA TLDSVNYIRD IILDVKGERK
     DFRVFTGLDQ HFLNTLILGG DGGIMACANF APELHLRLYK AFNEKRFEEA FEYSRKLAKL
     SKVYDIASSF GSAIKLAMRV RGFSIKPVLR PPYTMDGKEV EEKVRALLLE VL