ID   DAPAL_THEON             Reviewed;         293 AA.
AC   B6YU51;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Uncharacterized DapA-like lyase TON_0506;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=TON_0506;
OS   Thermococcus onnurineus (strain NA1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1;
RX   PubMed=18790866; DOI=10.1128/jb.00746-08;
RA   Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H.,
RA   Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J.,
RA   Colwell R.R., Kim S.-J., Lee J.-H.;
RT   "The complete genome sequence of Thermococcus onnurineus NA1 reveals a
RT   mixed heterotrophic and carboxydotrophic metabolism.";
RL   J. Bacteriol. 190:7491-7499(2008).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; CP000855; ACJ15993.1; -; Genomic_DNA.
DR   RefSeq; WP_012571465.1; NC_011529.1.
DR   AlphaFoldDB; B6YU51; -.
DR   SMR; B6YU51; -.
DR   STRING; 523850.TON_0506; -.
DR   EnsemblBacteria; ACJ15993; ACJ15993; TON_0506.
DR   GeneID; 7016803; -.
DR   KEGG; ton:TON_0506; -.
DR   PATRIC; fig|523850.10.peg.507; -.
DR   eggNOG; arCOG04172; Archaea.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   OMA; YYGYGGF; -.
DR   OrthoDB; 65776at2157; -.
DR   Proteomes; UP000002727; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   PROSITE; PS00666; DHDPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Schiff base.
FT   CHAIN           1..293
FT                   /note="Uncharacterized DapA-like lyase TON_0506"
FT                   /id="PRO_1000124074"
FT   ACT_SITE        43
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        105
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        131
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        159
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   293 AA;  32888 MW;  9AC933618EB48325 CRC64;
     MRGVIVPLVT PFNEDYSIDV PALEEHIDFL QKAGVHGIFI NATTGEFTSL SVEERKFLAE
     KGRELVNTTF YLVGTASTNT FEVIELTKHA QDLGADYVVI APPYYCPLNE TALFRHYSMV
     AERTDIPIIL YNIPSCANPL SVQLIKRLAL EYSNIAGVKE TIDSVNHVRD VIIEVKGERE
     DFMVFTGLDQ HFLNTLILGG DGGIMACANF APEVHLALYK AFQEKRFKDA FIYAQKLARL
     SKVYDLASSF GSAIKLAMSL RGFSIKPVLR PPYIIDGDEV KEEIRKLLRE VLY