ID   DAPAL_THEPD             Reviewed;         301 AA.
AC   A1S0T1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Uncharacterized DapA-like lyase Tpen_1666;
DE            EC=4.-.-.-;
GN   Name=dapAL; OrderedLocusNames=Tpen_1666;
OS   Thermofilum pendens (strain DSM 2475 / Hrk 5).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermofilales; Thermofilaceae;
OC   Thermofilum.
OX   NCBI_TaxID=368408;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2475 / Hrk 5;
RX   PubMed=18263724; DOI=10.1128/jb.01949-07;
RA   Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E.,
RA   Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M.,
RA   Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B.,
RA   Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.;
RT   "Genome sequence of Thermofilum pendens reveals an exceptional loss of
RT   biosynthetic pathways without genome reduction.";
RL   J. Bacteriol. 190:2957-2965(2008).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; CP000505; ABL79061.1; -; Genomic_DNA.
DR   RefSeq; WP_011753326.1; NC_008698.1.
DR   AlphaFoldDB; A1S0T1; -.
DR   SMR; A1S0T1; -.
DR   STRING; 368408.Tpen_1666; -.
DR   EnsemblBacteria; ABL79061; ABL79061; Tpen_1666.
DR   GeneID; 4601248; -.
DR   KEGG; tpe:Tpen_1666; -.
DR   eggNOG; arCOG04172; Archaea.
DR   HOGENOM; CLU_049343_5_1_2; -.
DR   OMA; YYGYGGF; -.
DR   OrthoDB; 65776at2157; -.
DR   Proteomes; UP000000641; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Reference proteome; Schiff base.
FT   CHAIN           1..301
FT                   /note="Uncharacterized DapA-like lyase Tpen_1666"
FT                   /id="PRO_0000340998"
FT   ACT_SITE        47
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        136
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        165
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   301 AA;  33347 MW;  6E7216012DC4BFF7 CRC64;
     MSARFYGVIS PFITPFREDL SLDREAVAWL ARYQAEKGVH GIFPNSTTGE FVHLSREEAV
     EVTRLVLEAV GGKVWVIPGI SANYTEDSVA LGRTFKDLGV DGAVVTPPYF FKVSPERLKV
     HFSTILEKVD LPIIVYNIPA TTGINIPVGL YLELAKEHSN LAGAKATVES FTYFRQLVQV
     VKAERKDFAV LTGLDDLLLP VLMMGGDGGI MALANAAPQI HREVYDAYRS GDLKRALEAW
     HKLLRLVRVY DYATSFPTSV KTLLKVMGAP VKPYARTPLT PETREVEEKI AQIARELGLK
     I