ACT2_CAEEL
ID ACT2_CAEEL Reviewed; 376 AA.
AC P10984; O45744;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Actin-2;
DE Flags: Precursor;
GN Name=act-2; ORFNames=T04C12.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2795655; DOI=10.1016/0022-2836(89)90503-2;
RA Krause M., Wild M., Rosenzweig B., Hirsh D.;
RT "Wild-type and mutant actin genes in Caenorhabditis elegans.";
RL J. Mol. Biol. 208:381-392(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-83.
RX PubMed=6302275; DOI=10.1016/0022-2836(83)90056-6;
RA Files J.G., Carr S., Hirsh D.;
RT "Actin gene family of Caenorhabditis elegans.";
RL J. Mol. Biol. 164:355-375(1983).
CC -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC various types of cell motility and are ubiquitously expressed in all
CC eukaryotic cells.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- MISCELLANEOUS: In this organism there are four genes coding for actin.
CC The sequences coded by genes 1 and 3 are identical. There are a few
CC variations in the actins coded by genes 2 and 4.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; X16797; CAA34718.1; -; Genomic_DNA.
DR EMBL; Z81584; CAB04675.1; -; Genomic_DNA.
DR EMBL; J01043; AAA27888.1; -; Genomic_DNA.
DR PIR; S16709; S16709.
DR PIR; T24448; T24448.
DR RefSeq; NP_505818.1; NM_073417.5.
DR AlphaFoldDB; P10984; -.
DR SMR; P10984; -.
DR BioGRID; 44561; 54.
DR DIP; DIP-25116N; -.
DR IntAct; P10984; 5.
DR STRING; 6239.T04C12.5.1; -.
DR EPD; P10984; -.
DR PaxDb; P10984; -.
DR PeptideAtlas; P10984; -.
DR PRIDE; P10984; -.
DR EnsemblMetazoa; T04C12.5.1; T04C12.5.1; WBGene00000064.
DR GeneID; 179534; -.
DR UCSC; T04C12.5; c. elegans.
DR CTD; 179534; -.
DR WormBase; T04C12.5; CE13150; WBGene00000064; act-2.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00950000182960; -.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; P10984; -.
DR OMA; WISRTEY; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; P10984; -.
DR Reactome; R-CEL-190873; Gap junction degradation.
DR Reactome; R-CEL-196025; Formation of annular gap junctions.
DR Reactome; R-CEL-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-CEL-3928662; EPHB-mediated forward signaling.
DR Reactome; R-CEL-437239; Recycling pathway of L1.
DR Reactome; R-CEL-4420097; VEGFA-VEGFR2 Pathway.
DR Reactome; R-CEL-446353; Cell-extracellular matrix interactions.
DR Reactome; R-CEL-5626467; RHO GTPases activate IQGAPs.
DR Reactome; R-CEL-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-CEL-5663220; RHO GTPases Activate Formins.
DR Reactome; R-CEL-5674135; MAP2K and MAPK activation.
DR Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-CEL-9035034; RHOF GTPase cycle.
DR SignaLink; P10984; -.
DR PRO; PR:P10984; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000064; Expressed in embryo and 3 other tissues.
DR GO; GO:0005884; C:actin filament; IDA:WormBase.
DR GO; GO:0005938; C:cell cortex; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005524; F:ATP binding; ISS:WormBase.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IMP:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase.
DR GO; GO:0040011; P:locomotion; IMP:WormBase.
DR GO; GO:0007111; P:meiosis II cytokinesis; IMP:WormBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IGI:WormBase.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00406; ACTINS_1; 1.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 3: Inferred from homology;
KW Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Reference proteome.
FT PROPEP 1..2
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000000652"
FT CHAIN 3..376
FT /note="Actin-2"
FT /id="PRO_0000000653"
FT MOD_RES 3
FT /note="N-acetylaspartate"
FT /evidence="ECO:0000250"
FT CONFLICT 10..11
FT /note="VV -> IL (in Ref. 1; CAA34718)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 41778 MW; 69D9209F0D5C3190 CRC64;
MCDDDVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM
TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THTVPIYEGY ALPHAILRLD
LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS
YELPDGQVIT VGNERFRCPE ALFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK
QEYDESGPSI VHRKCF
