ID   ACT2_HALRO              Reviewed;         378 AA.
AC   P27130;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Actin, muscle 2/4/4A;
GN   Name=MA2;
GN   and
GN   Name=MA4;
GN   and
GN   Name=MA4A;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Kusakabe T., Suzuki J., Saiga H., Jeffery W.R., Makabe K.W., Satoh N.;
RT   "Temporal and spatial expression of a muscle actin gene during
RT   embryogenesis of the ascidian Halocynthia roretzi.";
RL   Dev. Growth Differ. 33:227-234(1991).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- FUNCTION: Multiple isoforms are involved in various cellular functions
CC       such as cytoskeleton structure, cell mobility, chromosome movement and
CC       muscle contraction.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; D10067; BAA00956.1; -; mRNA.
DR   EMBL; D10886; BAA01708.1; -; Genomic_DNA.
DR   EMBL; D10887; BAA01709.1; -; Genomic_DNA.
DR   AlphaFoldDB; P27130; -.
DR   SMR; P27130; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Muscle protein; Nucleotide-binding.
FT   CHAIN           1..378
FT                   /note="Actin, muscle 2/4/4A"
FT                   /id="PRO_0000088947"
SQ   SEQUENCE   378 AA;  42014 MW;  4BC7DF27E76C55D2 CRC64;
     MSDGEEDTTA IVCDNGSGLV KSGFAGDDAP RAVFPSIVGR PRHQGVMVGM GQKDSYVGDE
     AQSKRGILTL KYPIEHGIIT NWDDMEKIWH HTFYNELRVA PEEHPTLLTE APLNPKANRE
     KMTQIMFETF NVPAMYVAIQ AVLSLYASGR TTGIVLDAGD GVSHNVPIYE GYALPHAIAR
     LDLAGRDLTD YLMKILTERG YSFVTTAERE IVRDIKEKLC YVALDFEQEM ATAASSTSLE
     KSYELPDGQV ITIGNERFRC PETLFQPSFI GMESAGIHET TYNSIMKCDI DIRKDLYANN
     VLSGGTTMYP GIADRMQKEI TALAPSTMKI KIIAPPERKY SVWIGGSILA SLSTFQQMWI
     SKQEYDEAGP SIVHRKCF