ID   ACT2_MOLOC              Reviewed;         378 AA.
AC   Q25472;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Actin, muscle-type;
DE   AltName: Full=A2;
OS   Molgula oculata (Sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Molgulidae; Molgula.
OX   NCBI_TaxID=27575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Gonad;
RX   PubMed=9060395; DOI=10.1007/pl00006146;
RA   Kusakabe T., Araki I., Satoh N., Jeffery W.R.;
RT   "Evolution of chordate actin genes: evidence from genomic organization and
RT   amino acid sequences.";
RL   J. Mol. Evol. 44:289-298(1997).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells. Multiple isoforms are involved in various cellular
CC       functions such as cytoskeleton structure, cell mobility, chromosome
CC       movement and muscle contraction.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; D85743; BAA12860.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q25472; -.
DR   SMR; Q25472; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Muscle protein; Nucleotide-binding.
FT   CHAIN           1..378
FT                   /note="Actin, muscle-type"
FT                   /id="PRO_0000088965"
SQ   SEQUENCE   378 AA;  42263 MW;  D550F523AAA1F505 CRC64;
     MEDEEEEQTA LVCDNGSGLV KAGFAGDDAP RAVFPSIVGR PRHQGVMVGM GQKDSYVGDE
     AQSKRGILTL KYPIEHGIIT NWDDMEKIWH HTFYNELRVA PEEHPVLLTE APLNPKANRE
     KMTQIMFETF NVPAMYVAIQ AVLSLYASGR TTGIVLDSGD GVSHNVPIYE GYALPHAIMR
     LDLAGRDLTD YLMKILTERG YSFVTTAERE IVRDIKEKLC YVALDFEQEM ATAASSSSLE
     KSYELPDGQV ITIGNERFRC PETMFQPSFI GMESSGVHET TYNSIMKCDI DIRKDLYANN
     VLSGGTTMYP GIADRMQKEI TALAPSTMKI KIIAPPERKY SVWIGGSILA SLSTFQQMWI
     TKQEYDESGP SIVHRKCF