ID   ACT2_NAEFO              Reviewed;         371 AA.
AC   P27132;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Actin-2;
DE   AltName: Full=Actin II;
DE   Flags: Fragment;
OS   Naegleria fowleri (Brain eating amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5763;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 30894 / Lee;
RA   Ahn J., Hu W.-N., Kopachik W.J., Band R.N.;
RT   "Cloning and characterization of two virulent-related actin genes in
RT   Naegleria fowleri.";
RL   Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; M90312; AAA29383.1; -; mRNA.
DR   AlphaFoldDB; P27132; -.
DR   SMR; P27132; -.
DR   PRIDE; P27132; -.
DR   VEuPathDB; AmoebaDB:FDP41_006065; -.
DR   VEuPathDB; AmoebaDB:NF0132150; -.
DR   VEuPathDB; AmoebaDB:NfTy_067420; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           <1..371
FT                   /note="Actin-2"
FT                   /id="PRO_0000088967"
FT   NON_TER         1
SQ   SEQUENCE   371 AA;  41153 MW;  EF128525C9B525C5 CRC64;
     VQALEVDNGS GMCKAGFAGD DAPGAVFPSI IGRPKQKSIM VGMGNKDAYV GDEVQSKRGI
     LIFKYPIQHG IVTNWDDMEK IWHHTFYNEL RVAPEEHPVL LTEAPLNPKA NREKMTQIMF
     ETFSVPAMYV AIQAVLSLYA SGRTTGIVLD SGDGVSHTVP IYEGYALPHA ILRLDLAGRD
     LTDYLIEDSH GTCYSFNTTA ERECQRDIKG KALLYCFDFE QEMKIAAESS SVEKLYELPD
     GNVITVGNER FRCPEVLFQP NFIGMEAAGV HETTFNSIGK CDIHIRKDLY GNVVLSGGTT
     MFEGIAERMT KELTNMAPAS MKIKVVAPPE RKYSVWIGGS ILASLSTFQQ MWITKEEYED
     AGPGIVHRES F