ID   ACT2_PHYIN              Reviewed;         375 AA.
AC   P22132;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Actin-2;
GN   Name=ACTB;
OS   Phytophthora infestans (Potato late blight agent) (Botrytis infestans).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2055461; DOI=10.1016/0378-1119(91)90355-f;
RA   Unkles S.E., Moon R.P., Hawkins A.R., Duncan J.M., Kinghorn J.R.;
RT   "Actin in the oomycetous fungus Phytophthora infestans is the product of
RT   several genes.";
RL   Gene 100:105-112(1991).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- TISSUE SPECIFICITY: ACTA and ACTB are actively transcribed in mycelium,
CC       sporangia and germinating cysts but only at a low level in the case of
CC       ACTB.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; M59716; AAA33750.1; -; Genomic_DNA.
DR   PIR; JE0415; JE0415.
DR   AlphaFoldDB; P22132; -.
DR   SMR; P22132; -.
DR   PRIDE; P22132; -.
DR   VEuPathDB; FungiDB:PITG_15078; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..375
FT                   /note="Actin-2"
FT                   /id="PRO_0000088985"
SQ   SEQUENCE   375 AA;  41958 MW;  927121A8EA3F3A95 CRC64;
     MDDDIQAVVI DNGSGMCKAG FAGDDAPRAV FPSIVGMPKH LGIMVGMNQK DAYIGDEAQA
     KRGVLTLRYP IEHGIVTNWD DMEKIWSHTF YNELRVAPEE HPVLLTEAPL NPKANRERMT
     QIMFETFNVP AMYVNIQAVL SLYASGRTTG CVLDSGDGVS HTVPIYEGYA LPHAIVRLDL
     AGRDLTDYMM KILTERGYSF TTTAEREIVR DIKEKLTYVA MDFDEEMEKS TRSSALDKTY
     ELPDGNVIVI GNERFRTPEV LFNPSMIGRE CSGVHECAFQ TIMKCDVDIR RDLYSNVVLS
     GGSTMFPGIG ERMTKEVIKL APTAMKVKII TPPERKYSVW IGGSILASLA TFQHMWISKT
     EYDESGPSIV HRKCF