ID   ACT2_SCHMA              Reviewed;         376 AA.
AC   P53471;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Actin-2;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=LE;
RX   PubMed=8720181; DOI=10.1016/0166-6851(95)02508-1;
RA   Oliveira G.C., Kemp W.M.;
RT   "Cloning of two actin genes from Schistosoma mansoni.";
RL   Mol. Biochem. Parasitol. 75:119-122(1995).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; U19945; AAC46966.1; -; mRNA.
DR   AlphaFoldDB; P53471; -.
DR   SMR; P53471; -.
DR   EnsemblMetazoa; Smp_307010.1; Smp_307010.1; Smp_307010.
DR   EnsemblMetazoa; Smp_307020.1; Smp_307020.1; Smp_307020.
DR   WBParaSite; Smp_307010.1; Smp_307010.1; Smp_307010.
DR   WBParaSite; Smp_307020.1; Smp_307020.1; Smp_307020.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   OMA; KCDESIC; -.
DR   PhylomeDB; P53471; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   ExpressionAtlas; P53471; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..376
FT                   /note="Actin-2"
FT                   /id="PRO_0000089006"
SQ   SEQUENCE   376 AA;  41741 MW;  3F445C71453F9DF8 CRC64;
     MADEEVQALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
     SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM
     TQIMFETFNT PAMYVGIQAV LSLYASGRTT GIVLDSGDGV THTVPIYEGY ALPHAILRLD
     LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS
     YELPDGQVIT IGNERFRCPE ALFQPSFLGM ESAGVHETTF NSIMKCDVDI RKDLYANTVL
     SGGTTMFPGI ADRMQKEITA LAPSTMKIKI VAPPERKYSV WIGGSILASL STFQQMWISK
     QEYDESGPGI VHRKCF