ACT3_DICDI
ID ACT3_DICDI Reviewed; 376 AA.
AC P07829; Q54HE6;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Actin-3;
DE AltName: Full=Actin-3-sub 1;
GN Name=act3; Synonyms=act3-1; ORFNames=DDB_G0289487;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3003365; DOI=10.1016/0022-2836(85)90108-1;
RA Romans P., Firtel R.A.;
RT "Organization of the actin multigene family of Dictyostelium discoideum and
RT analysis of variability in the protein coding regions.";
RL J. Mol. Biol. 186:321-335(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51.
RX PubMed=293714; DOI=10.1073/pnas.76.12.6206;
RA Firtel R.A., Timm R., Kimmel A.R., McKeown M.;
RT "Unusual nucleotide sequences at the 5' end of actin genes in Dictyostelium
RT discoideum.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:6206-6210(1979).
CC -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC various types of cell motility and are ubiquitously expressed in all
CC eukaryotic cells. Multiple isoforms are involved in various cellular
CC functions such as cytoskeleton structure, cell mobility, chromosome
CC movement and muscle contraction.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; X03283; CAA27033.1; -; Genomic_DNA.
DR EMBL; AAFI02000141; EAL62675.1; -; Genomic_DNA.
DR EMBL; V00182; CAA23478.1; -; Genomic_DNA.
DR PIR; C23412; C23412.
DR RefSeq; XP_636192.1; XM_631100.1.
DR AlphaFoldDB; P07829; -.
DR SMR; P07829; -.
DR STRING; 44689.DDB0220458; -.
DR PaxDb; P07829; -.
DR PRIDE; P07829; -.
DR EnsemblProtists; EAL62675; EAL62675; DDB_G0289487.
DR GeneID; 8627179; -.
DR KEGG; ddi:DDB_G0289487; -.
DR dictyBase; DDB_G0289487; act3.
DR eggNOG; KOG0676; Eukaryota.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; P07829; -.
DR OMA; PNIMVGM; -.
DR PhylomeDB; P07829; -.
DR Reactome; R-DDI-114608; Platelet degranulation.
DR Reactome; R-DDI-196025; Formation of annular gap junctions.
DR Reactome; R-DDI-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-DDI-5626467; RHO GTPases activate IQGAPs.
DR Reactome; R-DDI-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DDI-9013418; RHOBTB2 GTPase cycle.
DR PRO; PR:P07829; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:dictyBase.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0060187; C:cell pole; IDA:dictyBase.
DR GO; GO:0005911; C:cell-cell junction; IDA:dictyBase.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IDA:dictyBase.
DR GO; GO:0032009; C:early phagosome; IDA:dictyBase.
DR GO; GO:0061836; C:intranuclear rod; IDA:dictyBase.
DR GO; GO:0030027; C:lamellipodium; IDA:dictyBase.
DR GO; GO:0001891; C:phagocytic cup; IDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
DR GO; GO:0032010; C:phagolysosome; IDA:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017022; F:myosin binding; ISS:dictyBase.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:dictyBase.
DR GO; GO:0000902; P:cell morphogenesis; TAS:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IEP:dictyBase.
DR GO; GO:0001778; P:plasma membrane repair; IDA:dictyBase.
DR GO; GO:0051591; P:response to cAMP; IDA:dictyBase.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00406; ACTINS_1; 1.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..376
FT /note="Actin-3"
FT /id="PRO_0000088924"
FT CONFLICT 31
FT /note="V -> L (in Ref. 3; CAA23478)"
FT /evidence="ECO:0000305"
FT CONFLICT 115
FT /note="A -> R (in Ref. 1; CAA27033)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="P -> S (in Ref. 1; CAA27033)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 41841 MW; 193CDF20641BDBE5 CRC64;
MESEDVQALV IDNGSGMCKA GFAGDDAPRA VFPSIVGRPR YTGVMVGMGQ KDSYIGDEAQ
SRKGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM
TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV SHTVPIYEGY SLPHAILRLD
LAGRDLTDYM MKILTERGYS FTTTAEREIV RDIKEKLAYV ALDFEAELQT AASSSALEKS
YELPDGQVIT IGNERFRCPE ALFQPSFLGM ESAGIHETTY NSIMKCDVDI RKDLYSNVVL
SGGSTMFPGI ADRMNKELTA LAPSTMKIKI IAPPERKYSV WIGGSILASL PTFQQMWISK
EEYDESGPSI VHRKCF
