ID   3609L_ASFK5             Reviewed;         319 AA.
AC   P0C9P1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Protein MGF 360-9L;
GN   OrderedLocusNames=032;
OS   African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561445;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. In addition, inhibits IFN-
CC       beta-induced IFN-stimulated genes (ISGs) transcription.
CC       Mechanistically, degrades host STAT1 and STAT2 through apoptosis and
CC       ubiquitin-proteasome pathways respectively.
CC       {ECO:0000250|UniProtKB:Q65137}.
CC   -!- SUBUNIT: Interacts with host STAT1; this interaction mediates STAT1
CC       degradation through apoptosis. Interacts with host STAT2; this
CC       interaction mediates STAT2 degradation through the proteasome.
CC       {ECO:0000250|UniProtKB:Q65137}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:Q65137}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C9P1; -.
DR   PRIDE; P0C9P1; -.
DR   Proteomes; UP000000861; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host STAT1 by virus; Inhibition of host STAT2 by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..319
FT                   /note="Protein MGF 360-9L"
FT                   /id="PRO_0000373269"
SQ   SEQUENCE   319 AA;  37676 MW;  B048704E65949B51 CRC64;
     MLSLQTLAKK ALAKQSVPEE YHYILKYCGL WWQNKPIHLC DYCNYVIVNS TPFKGELHLD
     VALIMAIKEN NHDLIRLFTE WGANIYYGLS CARTEYTQEL CRKLGAKDGL DKKDIFISLL
     HHKTSNNIIL CHEIFNKNPM LEILNMQDFG EEIHRELKHL IFYILDNVPI NTLNKYWYAI
     AVKYKLKRAI SFFYQTYDHL NMWRLMCAIS FNNVFDLHEI YEQKIVHMDI DKMMHLACME
     DDNFLTIYYC FVLGADIDQA INVTLWHHQT NNLCFCKDLK DLKEQNGLTA RPLLLPNITD
     PKKIYTMLKN YLPISSNSR