ID   3609L_ASFP4             Reviewed;         352 AA.
AC   P0C9P2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Protein MGF 360-9L;
GN   OrderedLocusNames=Pret-031;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. In addition, inhibits IFN-
CC       beta-induced IFN-stimulated genes (ISGs) transcription.
CC       Mechanistically, degrades host STAT1 and STAT2 through apoptosis and
CC       ubiquitin-proteasome pathways respectively.
CC       {ECO:0000250|UniProtKB:Q65137}.
CC   -!- SUBUNIT: Interacts with host STAT1; this interaction mediates STAT1
CC       degradation through apoptosis. Interacts with host STAT2; this
CC       interaction mediates STAT2 degradation through the proteasome.
CC       {ECO:0000250|UniProtKB:Q65137}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:Q65137}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C9P2; -.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm.
FT   CHAIN           1..352
FT                   /note="Protein MGF 360-9L"
FT                   /id="PRO_0000373270"
SQ   SEQUENCE   352 AA;  41424 MW;  2E54A992E756395E CRC64;
     MVLSLQTLAK KVLAGQRPTK CHPHFLKCYG LWWHNGPMIF DQNQKKIWSP IFTDGVHINA
     ALVKAAAENN YDLIKLFTEW GANIDYSLLS VNTERTRDLC RELGAKEQLK QEEVLYYFNT
     IKRNLTSSNI ILCHEVFSHN PILETINRTK LRGIIYEQLE ALMENTDILS ELLTKYWYGI
     AIEFNLTKAI HYFYQRYVHL HQWRLMYALF YNNVCDLHEL YAKEKIRMDM DEMLKWACRK
     NYNYLTIYYC CIVLGADINQ AMFHSIQFYN IGNMFFCIDL GANAIEEGKT LALQKDKSFI
     ASLLSINCYS MNDSLSLKET DPEVIKRMLK DYHSKNMSIA HKYYIKHGFN DI