ID   3609L_ASFWA             Reviewed;         352 AA.
AC   P0C9P0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Protein MGF 360-9L;
GN   OrderedLocusNames=War-029;
OS   African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561444;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages.
CC       {ECO:0000250|UniProtKB:Q65137}.
CC   -!- SUBUNIT: Interacts with host STAT1; this interaction mediates STAT1
CC       degradation through apoptosis. Interacts with host STAT2; this
CC       interaction mediates STAT2 degradation through the proteasome.
CC       {ECO:0000250|UniProtKB:Q65137}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:Q65137}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C9P0; -.
DR   Proteomes; UP000000858; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host STAT1 by virus; Inhibition of host STAT2 by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..352
FT                   /note="Protein MGF 360-9L"
FT                   /id="PRO_0000373268"
SQ   SEQUENCE   352 AA;  41464 MW;  AB7AFB1070710C4E CRC64;
     MVLSLQTLAK KVLAGQRPTK CHPHFLKCYG LWWHNGPMIF DQNQKKIWSP IFTDGVHINA
     ALVKAVAENN YDLIKLFTEW GANIDYSLLS VNTERTRDLC RELGAKEQLK QEEVLYYFNI
     IKRNLTSSNI ILCHEVFSHN PILETINRTK LRGIIYEQLE ALMENTDILS ELLTKYWYGI
     AIEFNLTKAI HYFYQRYVHL HQWRLMYALF YNNVCDLHEL YAKEKIRMDM DEMLKWACRK
     NYNYLTIYYC CIVLGADINQ AMFHSIQFYN IGNMFFCIDL GANAIEEGKT LALQKDKSFI
     ASLLSINCYS MNDSLSLKET DPEVIKRMLK DYHSKNMSIA HKYYIKHGFN DI