ID   361L_IIV6               Reviewed;         542 AA.
AC   Q91FG3;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable cysteine proteinase 361L;
DE            EC=3.4.-.-;
GN   ORFNames=IIV6-361L;
OS   Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Iridovirus.
OX   NCBI_TaxID=176652;
OH   NCBI_TaxID=6997; Acheta domesticus (House cricket).
OH   NCBI_TaxID=168631; Chilo suppressalis (Asiatic rice borer moth).
OH   NCBI_TaxID=6999; Gryllus bimaculatus (Two-spotted cricket).
OH   NCBI_TaxID=58607; Gryllus campestris.
OH   NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11448171; DOI=10.1006/viro.2001.0963;
RA   Jakob N.J., Mueller K., Bahr U., Darai G.;
RT   "Analysis of the first complete DNA sequence of an invertebrate iridovirus:
RT   coding strategy of the genome of Chilo iridescent virus.";
RL   Virology 286:182-196(2001).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=17239238; DOI=10.1186/1743-422x-4-11;
RA   Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.;
RT   "Comparative genomic analysis of the family Iridoviridae: re-annotating and
RT   defining the core set of iridovirus genes.";
RL   Virol. J. 4:11-11(2007).
CC   -!- FUNCTION: Probable cysteine protease.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088}.
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DR   EMBL; AF303741; AAK82221.1; -; Genomic_DNA.
DR   RefSeq; NP_149824.1; NC_003038.1.
DR   GeneID; 1733399; -.
DR   KEGG; vg:1733399; -.
DR   Proteomes; UP000001359; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   Pfam; PF00112; Peptidase_C1; 2.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Membrane; Protease; Reference proteome; Thiol protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..542
FT                   /note="Probable cysteine proteinase 361L"
FT                   /id="PRO_0000377499"
FT   TRANSMEM        520..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        172
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
FT   ACT_SITE        382
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
FT   ACT_SITE        414
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10088"
SQ   SEQUENCE   542 AA;  60620 MW;  7588C036640CCB5E CRC64;
     MTSIINQRWP LGNLMDGFPN GEKQNKLSFG GVPEKGYFEE FNKDPKYISF SGTPEKAYFE
     EFNRYRNIDE DDNRDTFPLF NEISSNPESE SYLQTFVDNV RINTDINFVS KTNSFSQNDL
     SYLNATYVDK SLSLELPIKF NWAKTTSADS PDVVAKKKLI SKPDNQYLCG SCWAVSVAGV
     VGDVFAVAGL VNWVPNISAT YALIHYPQGR CKGGDPATLL YNIANNGIPS KHCVDYSWCS
     QNRTCTTADS AAHFGSDLSP LIPKDRGCYF DSEHYIFKID SNIRTIVAGS GAIDVSNVQR
     TIKEYIYTTG PAVGGYIIFR NFTSKVPFGP HKGNSTFNVI NGGVYLEKAN YAQYRGEYGE
     HITEGLTFSS SNTDSDNYAG GHAISIMGWG IQPRIRVGNG PNDIADVPYW YCRNSWGTKW
     GMNGGYFKIA MYPYNRKSQF SKIVELMTPQ GQHIRLGGVL AFTVSNPPVL KKLPANKQPP
     NPNSLSKLLD YYKNDEDDIV TKLPNIVPPS DGKKSTTSKT NNWYIYALII IFILIIFFVL
     RK