ID   ACTD_PHYPO              Reviewed;         367 AA.
AC   P24263;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Actin, spherule isoform;
GN   Name=ARDD;
OS   Physarum polycephalum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC   Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX   NCBI_TaxID=5791;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1840544; DOI=10.1016/0378-1119(91)90568-v;
RA   Adam L., Laroche A., Barden A., Lemieux G., Pallotta D.;
RT   "An unusual actin-encoding gene in Physarum polycephalum.";
RL   Gene 106:79-86(1991).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- DEVELOPMENTAL STAGE: Highest levels of ardD mRNA in spherules, less in
CC       plasmodia.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; M59234; AAA29973.1; -; Genomic_DNA.
DR   PIR; JT0596; JT0596.
DR   AlphaFoldDB; P24263; -.
DR   SMR; P24263; -.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProt.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..367
FT                   /note="Actin, spherule isoform"
FT                   /id="PRO_0000088989"
SQ   SEQUENCE   367 AA;  40650 MW;  89D769BB9AE7954D CRC64;
     MEGEAVVIDN GSGMCKAGFA GDNTPRAMFP SIVGHPRHTE AMMEIGHKHS YVGDEAQSKR
     GILALKYPIE QGIVNNWDDM EQIWHHTFYN EMRVAPEEHP VLLTEAPLNP KANREKMTQI
     MFESFSAPAM YVAIQAVLSL RASGRTTGIV LDSGDGASHA VPIYEGCALP HAILRIDAAG
     RDLTHYLRLM LAERGYAFNT TAELEIVRDI KEKLAYVALD FEQEMQTASS LNYELPDGRV
     VTIGNERFRC SEVLFQSCFL GMESAGIPET TYNSIMKCDV DIRKDLFGNL VLSGGTTMVP
     GIADRVQKEL TAFEPTMKIK IIAPPGRQYS AWIGGSILAS LSTFEQMCIS KKEYNECGPS
     IVHRKCF