ID   ACTD_STRPU              Reviewed;         376 AA.
AC   P69005; P02573; P10991;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Actin, cytoskeletal 2B;
DE   AltName: Full=Actin, cytoskeletal IIB;
DE   Flags: Precursor;
GN   Name=CYIIB; Synonyms=SPEC3;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3148745; DOI=10.1007/bf02143499;
RA   Durica D.S., Garza D., Restrepo M.A., Hryniewicz M.M.;
RT   "DNA sequence analysis and structural relationships among the cytoskeletal
RT   actin genes of the sea urchin Strongylocentrotus purpuratus.";
RL   J. Mol. Evol. 28:72-86(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7111028; DOI=10.1093/nar/10.13.4081;
RA   Cooper A.D., Crain W.R. Jr.;
RT   "Complete nucleotide sequence of a sea urchin actin gene.";
RL   Nucleic Acids Res. 10:4081-4092(1982).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton.
CC   -!- DEVELOPMENTAL STAGE: Thought to be expressed early in embryogenesis.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M35323; AAA30042.1; -; Genomic_DNA.
DR   EMBL; J01202; AAA30034.1; -; Genomic_DNA.
DR   PIR; A03001; ATURS.
DR   RefSeq; NP_001032234.2; NM_001037157.2.
DR   RefSeq; NP_999634.1; NM_214469.1.
DR   RefSeq; NP_999693.1; NM_214528.1.
DR   RefSeq; XP_011663769.1; XM_011665467.1.
DR   RefSeq; XP_011663770.1; XM_011665468.1.
DR   AlphaFoldDB; P69005; -.
DR   SMR; P69005; -.
DR   STRING; 7668.SPU_009483-tr; -.
DR   EnsemblMetazoa; NM_001037157; NP_001032234; GeneID_373190.
DR   EnsemblMetazoa; XM_011665467; XP_011663769; GeneID_373190.
DR   EnsemblMetazoa; XM_030997000; XP_030852860; GeneID_373190.
DR   EnsemblMetazoa; XM_030997550; XP_030853410; LOC115929160.
DR   GeneID; 115917875; -.
DR   GeneID; 373190; -.
DR   GeneID; 373192; -.
DR   GeneID; 373297; -.
DR   KEGG; spu:115917875; -.
DR   KEGG; spu:373190; -.
DR   KEGG; spu:373192; -.
DR   CTD; 373190; -.
DR   CTD; 373297; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; P69005; -.
DR   OMA; WISRTEY; -.
DR   OrthoDB; 649708at2759; -.
DR   PhylomeDB; P69005; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   PROPEP          1..2
FT                   /note="Removed in mature form"
FT                   /id="PRO_0000000728"
FT   CHAIN           3..376
FT                   /note="Actin, cytoskeletal 2B"
FT                   /id="PRO_0000000729"
FT   MOD_RES         3
FT                   /note="N-acetylaspartate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        258
FT                   /note="A -> C (in Ref. 2; AAA30034)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   376 AA;  41799 MW;  7264B5F884F2741B CRC64;
     MCDDDVAALV IDNGSGMVKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
     SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM
     TQIMFETFNS PAMYVAIQAV LSLYASGRTT GIVFDSGDGV SHTVPIYEGY ALPHAILRLD
     LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMQT AASSSSLEKS
     YELPDGQVIT IGNERFRAPE ALFQPAFLGM ESAGIHETCY NSIMKCDVDI RKDLYANTVL
     SGGSTMFPGI ADRMQKEITA LAPPTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK
     QEYDESGPSI VHRKCF