ID   ACTHR_PAPHA             Reviewed;         126 AA.
AC   Q28928;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Adrenocorticotropic hormone receptor;
DE            Short=ACTH receptor;
DE            Short=ACTH-R;
DE   AltName: Full=Adrenocorticotropin receptor;
DE   AltName: Full=Melanocortin receptor 2;
DE            Short=MC2-R;
DE   Flags: Fragment;
GN   Name=MC2R;
OS   Papio hamadryas (Hamadryas baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Adrenal cortex;
RX   PubMed=8625902; DOI=10.1210/endo.137.4.8625902;
RA   Albrecht E.D., Aberdeen G.W., Babischkin J.S., Tilly J.L., Pepe G.J.;
RT   "Biphasic developmental expression of adrenocorticotropin receptor
RT   messenger ribonucleic acid levels in the baboon fetal adrenal gland.";
RL   Endocrinology 137:1292-1298(1996).
CC   -!- FUNCTION: Receptor for corticotropin (ACTH). This receptor is mediated
CC       by G proteins (G(s)) which activate adenylate cyclase (cAMP).
CC   -!- SUBUNIT: Interacts with MRAP; increasing ligand-sensitivity and
CC       generation of cAMP. Interacts with MRAP2; competing with MRAP for
CC       binding to MC2R and impairing the binding of corticotropin (ACTH) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; S81913; AAB36456.1; -; mRNA.
DR   AlphaFoldDB; Q28928; -.
DR   SMR; Q28928; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004978; F:corticotropin receptor activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   InterPro; IPR001168; ACTH_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR   PANTHER; PTHR22750:SF3; PTHR22750:SF3; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00534; MCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>126
FT                   /note="Adrenocorticotropic hormone receptor"
FT                   /id="PRO_0000069057"
FT   TRANSMEM        <1..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        26..34
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        56..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        81..102
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        103..123
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        124..>126
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         126
SQ   SEQUENCE   126 AA;  14217 MW;  675339655014A28B CRC64;
     VLPEEIFFTI SIVGVLENLI VLLAVFKNKN LQAPMYFFIC SLAISDMLGS LYKILENILI
     ILRNMGYLKP RGSFETTADD IIDSLFVLSL LGAIFSLSVI AADRYITIFH ALRYHSIVTM
     RRTVVV