ID   ACTL1_CAEEL             Reviewed;         360 AA.
AC   Q18008; A0A0K3AVG9;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 3.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=ACT1-like protein {ECO:0000312|WormBase:C15B12.6a};
GN   Name=actl-1 {ECO:0000312|WormBase:C15B12.6a};
GN   ORFNames=C15B12.6 {ECO:0000312|WormBase:C15B12.6a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH ILCR-1; ILCR-2 AND PIK-1, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=28099418; DOI=10.1038/nature20818;
RA   Chen C., Itakura E., Nelson G.M., Sheng M., Laurent P., Fenk L.A.,
RA   Butcher R.A., Hegde R.S., de Bono M.;
RT   "IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.";
RL   Nature 542:43-48(2017).
CC   -!- FUNCTION: May act as an adapter to facilitate downstream signaling for
CC       the receptor complex composed of ilcr-1 and ilcr-2, which is a
CC       signaling complex that modulates neuronal activity and animal behavior
CC       in response to sensory neuron input. {ECO:0000269|PubMed:28099418}.
CC   -!- SUBUNIT: Interacts with the receptor complex composed of ilcr-1 and
CC       ilcr-2. Also interacts with pik-1. {ECO:0000269|PubMed:28099418}.
CC   -!- INTERACTION:
CC       Q18008; Q9NA64: ilcr-1; NbExp=2; IntAct=EBI-324674, EBI-16877763;
CC       Q18008; Q10128: ilcr-2; NbExp=2; IntAct=EBI-324674, EBI-327172;
CC       Q18008; G5ECP4: pik-1; NbExp=3; IntAct=EBI-324674, EBI-324661;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a {ECO:0000312|WormBase:C15B12.6a};
CC         IsoId=Q18008-1; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:C15B12.6b};
CC         IsoId=Q18008-2; Sequence=VSP_059577;
CC   -!- TISSUE SPECIFICITY: Expressed in neurons.
CC       {ECO:0000305|PubMed:28099418}.
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DR   EMBL; BX284606; CCD64569.2; -; Genomic_DNA.
DR   EMBL; BX284606; CTQ87027.1; -; Genomic_DNA.
DR   RefSeq; NP_001300316.1; NM_001313387.1. [Q18008-2]
DR   RefSeq; NP_509094.3; NM_076693.3. [Q18008-1]
DR   AlphaFoldDB; Q18008; -.
DR   DIP; DIP-26461N; -.
DR   IntAct; Q18008; 3.
DR   STRING; 6239.C15B12.6; -.
DR   PaxDb; Q18008; -.
DR   PeptideAtlas; Q18008; -.
DR   EnsemblMetazoa; C15B12.6a.1; C15B12.6a.1; WBGene00015787. [Q18008-1]
DR   EnsemblMetazoa; C15B12.6b.1; C15B12.6b.1; WBGene00015787. [Q18008-2]
DR   GeneID; 182629; -.
DR   KEGG; cel:CELE_C15B12.6; -.
DR   UCSC; C15B12.6; c. elegans. [Q18008-1]
DR   CTD; 182629; -.
DR   WormBase; C15B12.6a; CE47363; WBGene00015787; actl-1. [Q18008-1]
DR   WormBase; C15B12.6b; CE50614; WBGene00015787; actl-1. [Q18008-2]
DR   eggNOG; ENOG502SFCB; Eukaryota.
DR   HOGENOM; CLU_763412_0_0_1; -.
DR   InParanoid; Q18008; -.
DR   OMA; IMHLRTS; -.
DR   OrthoDB; 1481493at2759; -.
DR   PRO; PR:Q18008; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00015787; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..360
FT                   /note="ACT1-like protein"
FT                   /id="PRO_0000444154"
FT   REGION          339..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..3
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059577"
SQ   SEQUENCE   360 AA;  41793 MW;  F8593B9CD6DC335D CRC64;
     MTKMKMDVTI ELDLDGDDWE EVDVLSDKCV EDILEDVHID DPILVSDVRI TLPANIRIKN
     FKKEIRDLIL ANLDVPTTVS AGSWQIVSSF LRGIEYSEIG GRERNSKLSW KPFEDMHAQI
     LVNALAYAQR VDILVKLKSY IDSNSYLKNV PEPMFAFADT DSMASTTTFS EYAEPVHSMN
     ARKKILLLHY ETTSKEKEDF KWFKCNLKNV LEKERKEGKD LEVFDVKVWE KDDRGNVFQE
     LEKHYDLFPH IVVCFNKSYI EATKPNSKSK MPQFRKSISD KLNVEFHMNG NRNLRGRCVL
     MSEVEKVTDT YWAAVTNQYP FPGSFEPFVK RLLRDGKVKK QSHNNANDHH EDSMNYSITQ