ID   ACTL9_RAT               Reviewed;         411 AA.
AC   Q6AY16;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Actin-like protein 9;
GN   Name=Actl9; Synonyms=Actl7c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Testis-specic protein that plays an important role in fusion
CC       of proacrosomal vesicles and perinuclear theca formation.
CC       {ECO:0000250|UniProtKB:Q8TC94}.
CC   -!- SUBUNIT: Interacts with ACTL7A. {ECO:0000250|UniProtKB:Q8TC94}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q8TC94}. Cytoplasm, cytoskeleton, perinuclear
CC       theca {ECO:0000250|UniProtKB:Q8TC94}. Note=Localizes predominantly in
CC       the equatorial segment of the sperm head and neck regions, with some
CC       localization in the acrosomal segment of the head. Colocalizes in the
CC       acrosomal and equatorial segments of sperm with ACTL7A. Colocalizes
CC       with PLCZ1 in the equatorial segment of the head of capacitated sperm.
CC       {ECO:0000250|UniProtKB:Q8TC94}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; BC079230; AAH79230.1; -; mRNA.
DR   RefSeq; NP_001013915.1; NM_001013893.1.
DR   AlphaFoldDB; Q6AY16; -.
DR   SMR; Q6AY16; -.
DR   STRING; 10116.ENSRNOP00000037574; -.
DR   iPTMnet; Q6AY16; -.
DR   PhosphoSitePlus; Q6AY16; -.
DR   PaxDb; Q6AY16; -.
DR   Ensembl; ENSRNOT00000031286; ENSRNOP00000037574; ENSRNOG00000026033.
DR   GeneID; 292516; -.
DR   KEGG; rno:292516; -.
DR   UCSC; RGD:1359476; rat.
DR   CTD; 292516; -.
DR   RGD; 1359476; LOC292516.
DR   eggNOG; KOG0676; Eukaryota.
DR   GeneTree; ENSGT00940000163012; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; Q6AY16; -.
DR   OMA; HHILENG; -.
DR   OrthoDB; 649708at2759; -.
DR   PhylomeDB; Q6AY16; -.
DR   TreeFam; TF354237; -.
DR   PRO; PR:Q6AY16; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000026033; Expressed in testis.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0033011; C:perinuclear theca; ISS:UniProtKB.
DR   GO; GO:0061827; C:sperm head; ISS:UniProtKB.
DR   GO; GO:0001675; P:acrosome assembly; ISS:UniProtKB.
DR   GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030074; ACTL9.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF194; PTHR11937:SF194; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Fertilization;
KW   Reference proteome.
FT   CHAIN           1..411
FT                   /note="Actin-like protein 9"
FT                   /id="PRO_0000332299"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  46102 MW;  44CF3943B4834B5B CRC64;
     MDVNGPKRWE PHRSLDLNPR STPVYKSPLQ EPCGVFGNKG TTKMSGVVID MGTGICKMGF
     AGQTRPTYIV RNIVGCQPKR RTTMEQPKME MFIGEAAHAR PELTLMHPVR NGIVVDWEAA
     EFIWRHILEN DLRLDTQDHP LLFTDPPFNP ASNREKLVEV AFESLHSPAI YVASQSVLSV
     YANGRVNGLV VDTGHGVSYT VPVFQGYNLP SGIQRMDLAG HYLTKFLAEK ILRSSFAVKK
     EDMDTMENIK QQYCYVALDF QKEQGRPDEK FRRCLKLPDG QMITVGKELF QCPELLFHPP
     DTSGPSSLGL PSMVEHSLST VPQELRADME QNVLLCGGSS LFTGFEGRFK TELLRRLGPE
     AHVVVVAQAN RNLSVWIGGS ILASLCAFQT RWVLREQYEE HGPDIVLRKC S