ID   ACTM_HELER              Reviewed;         376 AA.
AC   P53463;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Actin, cytoskeletal;
DE   AltName: Full=M;
DE   Flags: Precursor;
OS   Heliocidaris erythrogramma (Sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC   Heliocidaris.
OX   NCBI_TaxID=7634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9190067; DOI=10.1093/oxfordjournals.molbev.a025805;
RA   Kissinger J.C., Hahn J.-H., Raff R.A.;
RT   "Rapid evolution in a conserved gene family. Evolution of the actin gene
RT   family in the sea urchin genus Heliocidaris and related genera.";
RL   Mol. Biol. Evol. 14:654-665(1997).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U32352; AAA86869.1; -; Genomic_DNA.
DR   EMBL; U32348; AAA86869.1; JOINED; Genomic_DNA.
DR   EMBL; U32349; AAA86869.1; JOINED; Genomic_DNA.
DR   EMBL; U32350; AAA86869.1; JOINED; Genomic_DNA.
DR   EMBL; U32351; AAA86869.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; P53463; -.
DR   SMR; P53463; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   PROPEP          1..2
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000000680"
FT   CHAIN           3..376
FT                   /note="Actin, cytoskeletal"
FT                   /id="PRO_0000000681"
FT   MOD_RES         3
FT                   /note="N-acetylaspartate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   376 AA;  41748 MW;  6C74E2B4066E93F2 CRC64;
     MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
     SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM
     TQIMFETFNA PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THTVPIYEGY ALPHAILRLD
     LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYS ALDFEQEMAT AAASSSLEKS
     YELPDGQVIT IGNERFRCPE TLFQPAFIGM ESAGIHETTY NSIMKCDIDI RKDLYANTVL
     SGGTSMYPGI ADRMQKEITA LAPSSMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK
     QEYDESGPSI VHRKCF