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ACTN2_CHICK
ID   ACTN2_CHICK             Reviewed;         897 AA.
AC   P20111; Q90821;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 163.
DE   RecName: Full=Alpha-actinin-2;
DE   AltName: Full=Alpha-actinin skeletal muscle isoform 2;
DE   AltName: Full=F-actin cross-linking protein;
GN   Name=ACTN2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=3197725; DOI=10.1111/j.1432-1033.1988.tb14419.x;
RA   Arimura C., Suzuki T., Yanagisawa M., Imamura M., Hamada Y., Masaki T.;
RT   "Primary structure of chicken skeletal muscle and fibroblast alpha-actinins
RT   deduced from cDNA sequences.";
RL   Eur. J. Biochem. 177:649-655(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=1720388; DOI=10.1016/0014-4827(91)90418-t;
RA   Tokuue Y., Goto S., Imamura M., Obinata T., Masaki T., Endo T.;
RT   "Transfection of chicken skeletal muscle alpha-actinin cDNA into nonmuscle
RT   and myogenic cells: dimerization is not essential for alpha-actinin to bind
RT   to microfilaments.";
RL   Exp. Cell Res. 197:158-167(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 662-867 (ISOFORM 2).
RX   PubMed=1483465; DOI=10.1111/j.1432-1033.1992.tb17483.x;
RA   Parr T., Waites G.T., Patel B., Millake D.B., Critchley D.R.;
RT   "A chick skeletal-muscle alpha-actinin gene gives rise to two alternatively
RT   spliced isoforms which differ in the EF-hand Ca(2+)-binding domain.";
RL   Eur. J. Biochem. 210:801-809(1992).
CC   -!- FUNCTION: F-actin cross-linking protein which is thought to anchor
CC       actin to a variety of intracellular structures. This is a bundling
CC       protein (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; antiparallel.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P20111-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P20111-2; Sequence=VSP_012544;
CC   -!- PTM: Ubiquitinated by FBXL22, leading to proteasomal degradation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family. {ECO:0000305}.
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DR   EMBL; X13874; CAA32078.1; -; mRNA.
DR   EMBL; X59247; CAA41935.1; -; mRNA.
DR   EMBL; X68797; CAA48702.1; -; Genomic_DNA.
DR   EMBL; X68798; CAA48702.1; JOINED; Genomic_DNA.
DR   EMBL; X68799; CAA48702.1; JOINED; Genomic_DNA.
DR   EMBL; X68800; CAA48702.1; JOINED; Genomic_DNA.
DR   EMBL; X68801; CAA48702.1; JOINED; Genomic_DNA.
DR   EMBL; X68802; CAA48702.1; JOINED; Genomic_DNA.
DR   PIR; S02032; S02032.
DR   RefSeq; NP_990654.1; NM_205323.1. [P20111-1]
DR   AlphaFoldDB; P20111; -.
DR   SMR; P20111; -.
DR   STRING; 9031.ENSGALP00000023309; -.
DR   PaxDb; P20111; -.
DR   PRIDE; P20111; -.
DR   Ensembl; ENSGALT00000023354; ENSGALP00000023309; ENSGALG00000014463. [P20111-1]
DR   GeneID; 396263; -.
DR   KEGG; gga:396263; -.
DR   CTD; 88; -.
DR   VEuPathDB; HostDB:geneid_396263; -.
DR   eggNOG; KOG0035; Eukaryota.
DR   GeneTree; ENSGT00940000153968; -.
DR   HOGENOM; CLU_005217_1_1_1; -.
DR   InParanoid; P20111; -.
DR   OMA; IMILVDP; -.
DR   PhylomeDB; P20111; -.
DR   TreeFam; TF352676; -.
DR   PRO; PR:P20111; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000014463; Expressed in skeletal muscle tissue and 10 other tissues.
DR   ExpressionAtlas; P20111; baseline and differential.
DR   GO; GO:0030175; C:filopodium; IDA:UniProtKB.
DR   GO; GO:0030018; C:Z disc; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030035; P:microspike assembly; IDA:UniProtKB.
DR   CDD; cd00014; CH; 2.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.10.418.10; -; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00150; SPEC; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Actin-binding; Alternative splicing; Calcium; Cytoplasm; Metal-binding;
KW   Reference proteome; Repeat; Ubl conjugation.
FT   CHAIN           1..897
FT                   /note="Alpha-actinin-2"
FT                   /id="PRO_0000073437"
FT   DOMAIN          41..145
FT                   /note="Calponin-homology (CH) 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   DOMAIN          154..260
FT                   /note="Calponin-homology (CH) 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REPEAT          284..394
FT                   /note="Spectrin 1"
FT   REPEAT          404..509
FT                   /note="Spectrin 2"
FT   REPEAT          519..630
FT                   /note="Spectrin 3"
FT   REPEAT          640..743
FT                   /note="Spectrin 4"
FT   DOMAIN          756..791
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          792..827
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..257
FT                   /note="Actin-binding"
FT   BINDING         769
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         773
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         780
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         805
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         807
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         811
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   VAR_SEQ         792
FT                   /note="L -> LDESDNLHSDEFKACLISLGEVGNDLQ (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_012544"
SQ   SEQUENCE   897 AA;  104275 MW;  F4FAC12F7F4C8834 CRC64;
     MNSMNQIETN MQYTYNYEED EYMTQEEEWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT
     QIENIEEDFR NGLKLMLLLE VISGERLPKP DRGKMRFHKI ANVNKALDYI ASKGVKLVSI
     GAEEIVDGNV KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YRNVNIQNFH
     LSWKDGLGLC ALIHRHRPDL IDYSKLNKDD PIGNINLAME IAEKHLDIPK MLDAEDIVNT
     PKPDERAIMT YVSCFYHAFA GAEQAETAAN RICKVLAVNQ ENERLMEEYE RLASELLEWI
     RRTIPWLENR TPEKTMQAMQ KKLEDFRDYR RKHKPPKVQE KCQLEINFNT LQTKLRISNR
     PAFMPSEGKM VSDIAGAWQR LEQAEKGYEE WLLNEIRRLE RLEHLAEKFR QKASTHEQWA
     YGKEQILLQK DYESASLTEV RAMLRKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYHDAA
     SVNDRCQKIC DQWDSLGTLT QKRREALERT EKLLETIDQL HLEFAKRAAP FNNWMEGAME
     DLQDMFIVHS IEEIQSLISA HDQFKATLPE ADGERQAILS IQNEVEKVIQ SYSMRISASN
     PYSTVTVEEI RTKWEKVKQL VPQRDQSLQE ELARQHANER LRRQFAAQAN VIGPWIQTKM
     EEIARSSIEM TGPLEDQMNQ LKQYEQNIIN YKHNIDKLEG DHQLIQEALV FDNKHTNYTM
     EHIRVGWELL LTTIARTINE VETQILTRDA KGITQEQMND FRASFNHFDR RKNGLMDHDD
     FRACLISMGY DLGEAEFARI MSLVDPNGQG TVTFQSFIDF MTRETADTDT AEQVIASFRI
     LASDKPYILA DELRRELPPE QAQYCIKRMP QYTGPGSVPG ALDYTSFSSA LYGESDL
 
 
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