DAPH_ENTFA
ID DAPH_ENTFA Reviewed; 233 AA.
AC Q836H8;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase {ECO:0000255|HAMAP-Rule:MF_01691};
DE EC=2.3.1.89 {ECO:0000255|HAMAP-Rule:MF_01691};
DE AltName: Full=Tetrahydrodipicolinate N-acetyltransferase {ECO:0000255|HAMAP-Rule:MF_01691};
DE Short=THP acetyltransferase {ECO:0000255|HAMAP-Rule:MF_01691};
DE Short=Tetrahydropicolinate acetylase {ECO:0000255|HAMAP-Rule:MF_01691};
GN Name=dapH {ECO:0000255|HAMAP-Rule:MF_01691}; OrderedLocusNames=EF_1133;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: Catalyzes the transfer of an acetyl group from acetyl-CoA to
CC tetrahydrodipicolinate. {ECO:0000255|HAMAP-Rule:MF_01691}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA +
CC L-2-acetamido-6-oxoheptanedioate; Xref=Rhea:RHEA:13085,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16845, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:58117; EC=2.3.1.89;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01691};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate
CC (acetylase route): step 1/3. {ECO:0000255|HAMAP-Rule:MF_01691}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family. DapH
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01691}.
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DR EMBL; AE016830; AAO80933.1; -; Genomic_DNA.
DR RefSeq; NP_814863.1; NC_004668.1.
DR RefSeq; WP_002386624.1; NZ_KE136528.1.
DR PDB; 3CJ8; X-ray; 1.95 A; A/B/C=2-233.
DR PDBsum; 3CJ8; -.
DR AlphaFoldDB; Q836H8; -.
DR SMR; Q836H8; -.
DR STRING; 226185.EF_1133; -.
DR EnsemblBacteria; AAO80933; AAO80933; EF_1133.
DR KEGG; efa:EF1133; -.
DR PATRIC; fig|226185.45.peg.2362; -.
DR eggNOG; COG2171; Bacteria.
DR HOGENOM; CLU_103751_0_0_9; -.
DR OMA; HLEYDRR; -.
DR UniPathway; UPA00034; UER00022.
DR EvolutionaryTrace; Q836H8; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0047200; F:tetrahydrodipicolinate N-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01691; DapH; 1.
DR InterPro; IPR019873; DapH.
DR InterPro; IPR013710; DapH_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR Pfam; PF08503; DapH_N; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF14602; Hexapep_2; 1.
DR SUPFAM; SSF51161; SSF51161; 1.
DR TIGRFAMs; TIGR03532; DapD_Ac; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Amino-acid biosynthesis;
KW Diaminopimelate biosynthesis; Lysine biosynthesis; Reference proteome;
KW Repeat; Transferase.
FT CHAIN 1..233
FT /note="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-
FT acetyltransferase"
FT /id="PRO_0000376656"
FT HELIX 2..12
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 18..25
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 36..40
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 42..50
FT /evidence="ECO:0007829|PDB:3CJ8"
FT HELIX 51..60
FT /evidence="ECO:0007829|PDB:3CJ8"
FT TURN 61..64
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 65..72
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 75..77
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 88..91
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 96..100
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 203..206
FT /evidence="ECO:0007829|PDB:3CJ8"
FT TURN 207..210
FT /evidence="ECO:0007829|PDB:3CJ8"
FT STRAND 211..215
FT /evidence="ECO:0007829|PDB:3CJ8"
SQ SEQUENCE 233 AA; 24618 MW; CE20F3EBA9B89DA2 CRC64;
MDAYEIIQYI GDAKKQTLVK VTLKGQLKEV TFPETIKVFN NCKTGTLFGD WADVKPFLEA
NKEKIEDYVV ENDARNSAIP FLDLKDINAR IEPGALIREK VEIGDQAVIM MGAILNIGAV
VGAGTMIDMG AVLGGRATVG KHCHIGAGTV LAGVIEPPSA APVVIENEVV IGANAVVLEG
VRVGEGAVVA AGAVVVEDVP AHTVVAGVPA KVIKQIDDKT KSKTEILEEL RKL
