ID   DAPL1_BOVIN             Reviewed;         107 AA.
AC   A2VEA7; Q4PP00;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Death-associated protein-like 1;
DE   AltName: Full=Early epithelial differentiation-associated protein;
GN   Name=DAPL1; Synonyms=EEDA;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Corneal epithelium;
RX   PubMed=15920738; DOI=10.1002/jcp.20433;
RA   Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.;
RT   "EEDA: a protein associated with an early stage of stratified epithelial
RT   differentiation.";
RL   J. Cell. Physiol. 206:103-111(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the early stages of epithelial
CC       differentiation or in apoptosis. {ECO:0000269|PubMed:15920738}.
CC   -!- TISSUE SPECIFICITY: Detected in the corneal epithelium, and only in
CC       trace amounts in the liver, bladder, brain, heart, and stomach.
CC       {ECO:0000269|PubMed:15920738}.
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DR   EMBL; DQ062556; AAY62365.1; -; mRNA.
DR   EMBL; BC133652; AAI33653.1; -; mRNA.
DR   RefSeq; NP_001020517.1; NM_001025346.1.
DR   AlphaFoldDB; A2VEA7; -.
DR   STRING; 9913.ENSBTAP00000043391; -.
DR   PaxDb; A2VEA7; -.
DR   Ensembl; ENSBTAT00000046063; ENSBTAP00000043391; ENSBTAG00000032481.
DR   GeneID; 574085; -.
DR   KEGG; bta:574085; -.
DR   CTD; 92196; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032481; -.
DR   VGNC; VGNC:27879; DAPL1.
DR   eggNOG; ENOG502S7Q6; Eukaryota.
DR   GeneTree; ENSGT00940000154574; -.
DR   HOGENOM; CLU_150759_0_0_1; -.
DR   InParanoid; A2VEA7; -.
DR   OMA; ERSHCPR; -.
DR   OrthoDB; 1490993at2759; -.
DR   TreeFam; TF329716; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000032481; Expressed in rumen papilla and 94 other tissues.
DR   ExpressionAtlas; A2VEA7; baseline and differential.
DR   GO; GO:0070513; F:death domain binding; IBA:GO_Central.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR   InterPro; IPR024130; DAP1/DAPL1.
DR   PANTHER; PTHR13177; PTHR13177; 1.
DR   Pfam; PF15228; DAP; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Differentiation; Reference proteome.
FT   CHAIN           1..107
FT                   /note="Death-associated protein-like 1"
FT                   /id="PRO_0000316834"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        106
FT                   /note="K -> N (in Ref. 1; AAY62365)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   107 AA;  11821 MW;  81FD3995F060B1D8 CRC64;
     MANEVQVQLS PLKGGHPPAV KAGGKRISKK QEIGILERHT KKTGLEKTSA TANVAKIQTM
     DALNDTLEKL SHKFPAVAHM AHQKPRPALE KVTPLKRIYI IQQPRKC