DAPL1_HUMAN
ID DAPL1_HUMAN Reviewed; 107 AA.
AC A0PJW8; A0PJW9; B9EIK6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Death-associated protein-like 1;
DE AltName: Full=Early epithelial differentiation-associated protein;
GN Name=DAPL1; Synonyms=EEDA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PRO-60.
RA Schulz H.L., Stojic J., Weber B.H.F.;
RT "Cloning and characterization of DAPL1.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-60.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RC TISSUE=Corneal epithelium;
RX PubMed=15920738; DOI=10.1002/jcp.20433;
RA Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.;
RT "EEDA: a protein associated with an early stage of stratified epithelial
RT differentiation.";
RL J. Cell. Physiol. 206:103-111(2006).
CC -!- FUNCTION: May play a role in the early stages of epithelial
CC differentiation or in apoptosis. {ECO:0000250}.
CC -!- INTERACTION:
CC A0PJW8; Q14192: FHL2; NbExp=3; IntAct=EBI-12840152, EBI-701903;
CC A0PJW8; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-12840152, EBI-10242151;
CC A0PJW8; O15116: LSM1; NbExp=3; IntAct=EBI-12840152, EBI-347619;
CC A0PJW8; Q969E8: TSR2; NbExp=3; IntAct=EBI-12840152, EBI-746981;
CC A0PJW8; Q15915: ZIC1; NbExp=3; IntAct=EBI-12840152, EBI-11963196;
CC -!- TISSUE SPECIFICITY: Expressed in hair follicle (at protein level).
CC {ECO:0000269|PubMed:15920738}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY324399; AAQ93012.1; -; mRNA.
DR EMBL; CH471058; EAX11424.1; -; Genomic_DNA.
DR EMBL; BC127682; AAI27683.1; -; mRNA.
DR EMBL; BC127683; AAI27684.1; -; mRNA.
DR EMBL; BC140719; AAI40720.1; -; mRNA.
DR CCDS; CCDS33307.1; -.
DR RefSeq; NP_001017920.2; NM_001017920.2.
DR AlphaFoldDB; A0PJW8; -.
DR BioGRID; 124918; 8.
DR IntAct; A0PJW8; 7.
DR STRING; 9606.ENSP00000309538; -.
DR iPTMnet; A0PJW8; -.
DR PhosphoSitePlus; A0PJW8; -.
DR BioMuta; DAPL1; -.
DR MassIVE; A0PJW8; -.
DR PaxDb; A0PJW8; -.
DR PeptideAtlas; A0PJW8; -.
DR PRIDE; A0PJW8; -.
DR ProteomicsDB; 65; -.
DR Antibodypedia; 54329; 122 antibodies from 17 providers.
DR DNASU; 92196; -.
DR Ensembl; ENST00000309950.8; ENSP00000309538.4; ENSG00000163331.12.
DR GeneID; 92196; -.
DR KEGG; hsa:92196; -.
DR MANE-Select; ENST00000309950.8; ENSP00000309538.4; NM_001017920.3; NP_001017920.2.
DR CTD; 92196; -.
DR DisGeNET; 92196; -.
DR GeneCards; DAPL1; -.
DR HGNC; HGNC:21490; DAPL1.
DR HPA; ENSG00000163331; Tissue enhanced (epididymis, esophagus, skin).
DR neXtProt; NX_A0PJW8; -.
DR OpenTargets; ENSG00000163331; -.
DR PharmGKB; PA134982815; -.
DR VEuPathDB; HostDB:ENSG00000163331; -.
DR eggNOG; ENOG502S7Q6; Eukaryota.
DR GeneTree; ENSGT00940000154574; -.
DR HOGENOM; CLU_150759_0_0_1; -.
DR InParanoid; A0PJW8; -.
DR OMA; HKFTATV; -.
DR OrthoDB; 1490993at2759; -.
DR PhylomeDB; A0PJW8; -.
DR TreeFam; TF329716; -.
DR PathwayCommons; A0PJW8; -.
DR SignaLink; A0PJW8; -.
DR BioGRID-ORCS; 92196; 8 hits in 998 CRISPR screens.
DR GenomeRNAi; 92196; -.
DR Pharos; A0PJW8; Tbio.
DR PRO; PR:A0PJW8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A0PJW8; protein.
DR Bgee; ENSG00000163331; Expressed in upper arm skin and 132 other tissues.
DR ExpressionAtlas; A0PJW8; baseline and differential.
DR Genevisible; A0PJW8; HS.
DR GO; GO:0070513; F:death domain binding; IBA:GO_Central.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR InterPro; IPR024130; DAP1/DAPL1.
DR PANTHER; PTHR13177; PTHR13177; 1.
DR Pfam; PF15228; DAP; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Differentiation; Reference proteome.
FT CHAIN 1..107
FT /note="Death-associated protein-like 1"
FT /id="PRO_0000316835"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 60
FT /note="L -> P (in dbSNP:rs9869)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_038402"
FT VARIANT 66
FT /note="A -> T (in dbSNP:rs12535)"
FT /id="VAR_038403"
SQ SEQUENCE 107 AA; 11880 MW; 2BB99D8DEB3FC7C3 CRC64;
MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA IANVAKIQTL
DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI IQQPRKC
