DAPL1_MOUSE
ID DAPL1_MOUSE Reviewed; 107 AA.
AC Q9D757;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Death-associated protein-like 1;
DE AltName: Full=Early epithelial differentiation-associated protein;
GN Name=Dapl1; Synonyms=Eeda;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Corneal epithelium;
RX PubMed=15920738; DOI=10.1002/jcp.20433;
RA Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.;
RT "EEDA: a protein associated with an early stage of stratified epithelial
RT differentiation.";
RL J. Cell. Physiol. 206:103-111(2006).
CC -!- FUNCTION: May play a role in the early stages of epithelial
CC differentiation or in apoptosis. {ECO:0000269|PubMed:15920738}.
CC -!- TISSUE SPECIFICITY: Expressed in hair follicle, corneal epithelium,
CC epidermis and footpad epithelium (at protein level).
CC {ECO:0000269|PubMed:15920738}.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed in outer cells of the two cell-
CC layer ectoderm at embryonic day 14.5. Detected only in the intermediate
CC cells, undetectable in the basal or outermost epidermal cells or the
CC occasional follicular buds. In 17.5 dpc and 18.5 dpc epidermis
CC expression is restricted to a single layer of suprabasal cells and is
CC absent in the granular cell layer. Also present in the differentiated
CC follicular cells at the apex of the 'horseshoeshaped' matrix. Detected
CC throughout the limbal and corneal epithelium at day 1 of postnatal
CC life, at day 5 of post-natal life it was no longer detected in the
CC limbal epithelium. {ECO:0000269|PubMed:15920738}.
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DR EMBL; AK009567; BAB26364.1; -; mRNA.
DR EMBL; AL845283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116916; AAI16917.1; -; mRNA.
DR EMBL; BC116920; AAI16921.1; -; mRNA.
DR CCDS; CCDS16053.1; -.
DR RefSeq; NP_083999.1; NM_029723.3.
DR AlphaFoldDB; Q9D757; -.
DR STRING; 10090.ENSMUSP00000028369; -.
DR PhosphoSitePlus; Q9D757; -.
DR EPD; Q9D757; -.
DR PaxDb; Q9D757; -.
DR PRIDE; Q9D757; -.
DR ProteomicsDB; 279824; -.
DR DNASU; 76747; -.
DR Ensembl; ENSMUST00000028369; ENSMUSP00000028369; ENSMUSG00000026989.
DR GeneID; 76747; -.
DR KEGG; mmu:76747; -.
DR UCSC; uc008jti.3; mouse.
DR CTD; 92196; -.
DR MGI; MGI:1923997; Dapl1.
DR VEuPathDB; HostDB:ENSMUSG00000026989; -.
DR eggNOG; ENOG502S7Q6; Eukaryota.
DR GeneTree; ENSGT00940000154574; -.
DR HOGENOM; CLU_150759_0_0_1; -.
DR InParanoid; Q9D757; -.
DR OMA; HKFTATV; -.
DR OrthoDB; 1490993at2759; -.
DR PhylomeDB; Q9D757; -.
DR TreeFam; TF329716; -.
DR BioGRID-ORCS; 76747; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Dapl1; mouse.
DR PRO; PR:Q9D757; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D757; protein.
DR Bgee; ENSMUSG00000026989; Expressed in epithelium of lens and 111 other tissues.
DR Genevisible; Q9D757; MM.
DR GO; GO:0070513; F:death domain binding; IBA:GO_Central.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR InterPro; IPR024130; DAP1/DAPL1.
DR PANTHER; PTHR13177; PTHR13177; 1.
DR Pfam; PF15228; DAP; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Differentiation; Reference proteome.
FT CHAIN 1..107
FT /note="Death-associated protein-like 1"
FT /id="PRO_0000316836"
SQ SEQUENCE 107 AA; 11813 MW; A383CAD35FC0E5B6 CRC64;
MANEVQVLPS PLKGRYAPAV KAGGMRISKK QEMGVLERHT KKTGLEKTSA ITNVAKIQML
DALTDTLDKL NHKFPATVHT AHQKPTPALE KAAPMKRAYI IQQPRKC
