DAR10_MOUSE
ID DAR10_MOUSE Reviewed; 91 AA.
AC Q64263; Q0VDL7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Alpha-defensin-related sequence 10;
DE AltName: Full=CRS4C-4;
DE AltName: Full=Cryptdin-related protein 4C-4;
DE AltName: Full=Defensin-related cryptdin-related sequence 10;
DE Flags: Precursor;
GN Name=Defa-rs10; Synonyms=Defcr-rs10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ; TISSUE=Small intestine;
RX PubMed=7896294; DOI=10.1006/geno.1994.1586;
RA Huttner K.M., Ouellette A.J.;
RT "A family of defensin-like genes codes for diverse cysteine-rich peptides
RT in mouse Paneth cells.";
RL Genomics 24:99-109(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Apparent precursor of a secreted, cationic, proline- and
CC cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike
CC cryptdin, the proposed mature peptide region lacks the structural motif
CC characteristic of defensins. It may have microbicidal activities (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Paneth cells of the small bowel.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; S77616; AAB33827.1; -; Genomic_DNA.
DR EMBL; S77750; AAB33827.1; JOINED; Genomic_DNA.
DR EMBL; U12565; AAA20978.1; -; Genomic_DNA.
DR EMBL; BC119615; AAI19616.1; -; mRNA.
DR EMBL; BC119616; AAI19617.1; -; mRNA.
DR RefSeq; NP_031871.1; NM_007845.3.
DR AlphaFoldDB; Q64263; -.
DR PRIDE; Q64263; -.
DR GeneID; 13219; -.
DR KEGG; mmu:13219; -.
DR CTD; 13219; -.
DR MGI; MGI:102516; Defa-rs10.
DR InParanoid; Q64263; -.
DR PhylomeDB; Q64263; -.
DR PRO; PR:Q64263; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q64263; protein.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0051873; P:killing by host of symbiont cells; ISO:MGI.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:1905710; P:positive regulation of membrane permeability; ISO:MGI.
DR GO; GO:0051289; P:protein homotetramerization; ISO:MGI.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Defensin; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..65
FT /evidence="ECO:0000255"
FT /id="PRO_0000006855"
FT PEPTIDE 66..91
FT /note="Alpha-defensin-related sequence 10"
FT /id="PRO_0000006856"
FT REPEAT 65..67
FT /note="1"
FT REPEAT 68..70
FT /note="2"
FT REPEAT 71..73
FT /note="3"
FT REPEAT 74..76
FT /note="4"
FT REPEAT 77..79
FT /note="5"
FT REPEAT 80..82
FT /note="6"
FT REPEAT 83..85
FT /note="7"
FT REGION 21..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..85
FT /note="7 X 3 AA tandem repeats of C-P-X"
SQ SEQUENCE 91 AA; 9777 MW; 8CA720F2404CAF08 CRC64;
MKKLVLLSAF VLLAFQVQAD SIQNTDEETK TEEQPGEENQ AMSVSFGDPE GSALQDAAVG
MARPCPPCPS CPSCPWCPMC PRCPSCKCNP K
