DAR12_MOUSE
ID DAR12_MOUSE Reviewed; 91 AA.
AC P50716; Q64110;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Alpha-defensin-related sequence 12;
DE AltName: Full=CRS4C5;
DE AltName: Full=Cryptdin-related protein 4C-5;
DE AltName: Full=Defensin-related cryptdin-related sequence 12;
DE Flags: Precursor;
GN Name=Defa-rs12; Synonyms=Defcr-rs12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ; TISSUE=Small intestine;
RX PubMed=7896294; DOI=10.1006/geno.1994.1586;
RA Huttner K.M., Ouellette A.J.;
RT "A family of defensin-like genes codes for diverse cysteine-rich peptides
RT in mouse Paneth cells.";
RL Genomics 24:99-109(1994).
CC -!- FUNCTION: Apparent precursor of a secreted, cationic, proline- and
CC cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike
CC cryptdin, the proposed mature peptide region lacks the structural motif
CC characteristic of defensins. It may have microbicidal activities (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Paneth cells of the small bowel.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; S77621; AAB33828.2; -; Genomic_DNA.
DR EMBL; S77618; AAB33828.2; JOINED; Genomic_DNA.
DR EMBL; U12566; AAA20979.1; -; Genomic_DNA.
DR RefSeq; NP_031872.1; NM_007846.1.
DR AlphaFoldDB; P50716; -.
DR PRIDE; P50716; -.
DR DNASU; 13221; -.
DR GeneID; 13221; -.
DR KEGG; mmu:13221; -.
DR CTD; 13221; -.
DR MGI; MGI:102514; Defa-rs12.
DR InParanoid; P50716; -.
DR PhylomeDB; P50716; -.
DR PRO; PR:P50716; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P50716; protein.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0051873; P:killing by host of symbiont cells; ISO:MGI.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:1905710; P:positive regulation of membrane permeability; ISO:MGI.
DR GO; GO:0051289; P:protein homotetramerization; ISO:MGI.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Defensin; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..65
FT /evidence="ECO:0000255"
FT /id="PRO_0000006857"
FT PEPTIDE 66..91
FT /note="Alpha-defensin-related sequence 12"
FT /id="PRO_0000006858"
FT REPEAT 65..67
FT /note="1"
FT REPEAT 68..70
FT /note="2"
FT REPEAT 71..73
FT /note="3"
FT REPEAT 74..76
FT /note="4"
FT REPEAT 77..79
FT /note="5"
FT REPEAT 83..85
FT /note="6"
FT REGION 65..88
FT /note="6 X 3 AA tandem repeats of C-P-X"
FT CONFLICT 56
FT /note="D -> DA (in Ref. 1; AAA20979)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 91 AA; 10146 MW; 519AA238699DBFC7 CRC64;
MKKLVLLSAF VLLAFQVQAD SIQNTDEEIK TEEQPGEENQ AVSISFGDPE GYALQDAAIR
RARRCPPCPS CLSCPWCPRC LRCPMCKCNP K
