ID   ACTOA_DICDI             Reviewed;          92 AA.
AC   Q55DU3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Actobindin-A;
GN   Name=abnA; ORFNames=DDB_G0270884;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA   Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA   Skelton J., Ivens A., Bozzaro S.;
RT   "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT   bacteria in Dictyostelium.";
RL   BMC Genomics 9:291-291(2008).
CC   -!- FUNCTION: Is able to bind two actin monomers at high concentrations of
CC       G-actin. Inhibits actin polymerization by sequestering G-actin and
CC       stabilizing actin dimers (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC       {ECO:0000269|PubMed:18559084}.
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DR   EMBL; AAFI02000005; EAL72792.1; -; Genomic_DNA.
DR   RefSeq; XP_646038.1; XM_640946.1.
DR   AlphaFoldDB; Q55DU3; -.
DR   PaxDb; Q55DU3; -.
DR   EnsemblProtists; EAL72792; EAL72792; DDB_G0270884.
DR   GeneID; 8616985; -.
DR   KEGG; ddi:DDB_G0270884; -.
DR   dictyBase; DDB_G0270884; abnA.
DR   eggNOG; ENOG502SBN0; Eukaryota.
DR   HOGENOM; CLU_175897_0_0_1; -.
DR   InParanoid; Q55DU3; -.
DR   OMA; VHVKENN; -.
DR   PRO; PR:Q55DU3; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0003779; F:actin binding; ISS:dictyBase.
DR   InterPro; IPR016365; Actobindin.
DR   InterPro; IPR003124; WH2_dom.
DR   Pfam; PF02205; WH2; 2.
DR   PIRSF; PIRSF002724; Actobindin; 1.
DR   SMART; SM00246; WH2; 2.
DR   PROSITE; PS51082; WH2; 2.
PE   2: Evidence at transcript level;
KW   Actin-binding; Reference proteome; Repeat.
FT   CHAIN           1..92
FT                   /note="Actobindin-A"
FT                   /id="PRO_0000383094"
FT   DOMAIN          3..20
FT                   /note="WH2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00406"
FT   DOMAIN          40..57
FT                   /note="WH2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00406"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          54..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   92 AA;  9817 MW;  8D7D086A1BB1B6B6 CRC64;
     MSAPNPLLAE INKGADLKHT ETQDKSAPKI GSDVHIKKND HASLLSEVEQ GAKLKHAETD
     DKSAPKINEN TTIKPNNHSA LLGEIKAKAA DS