ID   DASC_STRCO              Reviewed;         276 AA.
AC   Q9K489;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Diacetylchitobiose uptake system permease protein DasC {ECO:0000305};
GN   Name=dasC {ECO:0000303|PubMed:17351098};
GN   OrderedLocusNames=SCO5234 {ECO:0000312|EMBL:CAB94619.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=17351098; DOI=10.1128/aem.02612-06;
RA   Saito A., Shinya T., Miyamoto K., Yokoyama T., Kaku H., Minami E.,
RA   Shibuya N., Tsujibo H., Nagata Y., Ando A., Fujii T., Miyashita K.;
RT   "The dasABC gene cluster, adjacent to dasR, encodes a novel ABC transporter
RT   for the uptake of N,N'-diacetylchitobiose in Streptomyces coelicolor
RT   A3(2).";
RL   Appl. Environ. Microbiol. 73:3000-3008(2007).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=18957589; DOI=10.1099/mic.0.2008/019612-0;
RA   Saito A., Fujii T., Shinya T., Shibuya N., Ando A., Miyashita K.;
RT   "The msiK gene, encoding the ATP-hydrolysing component of N,N'-
RT   diacetylchitobiose ABC transporters, is essential for induction of
RT   chitinase production in Streptomyces coelicolor A3(2).";
RL   Microbiology 154:3358-3365(2008).
CC   -!- FUNCTION: Part of the ABC transporter complex DasABC-MsiK involved in
CC       N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the
CC       translocation of the substrate across the membrane.
CC       {ECO:0000305|PubMed:17351098}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MsiK),
CC       two transmembrane proteins (DasB and DasC) and a solute-binding protein
CC       (DasA). {ECO:0000305|PubMed:18957589}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Induced by (GlcNAc)2 and (GlcNAc)3.
CC       {ECO:0000269|PubMed:17351098}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; AL939123; CAB94619.1; -; Genomic_DNA.
DR   RefSeq; NP_629381.1; NC_003888.3.
DR   RefSeq; WP_003973737.1; NZ_VNID01000008.1.
DR   AlphaFoldDB; Q9K489; -.
DR   SMR; Q9K489; -.
DR   STRING; 100226.SCO5234; -.
DR   GeneID; 1100675; -.
DR   KEGG; sco:SCO5234; -.
DR   PATRIC; fig|100226.15.peg.5317; -.
DR   eggNOG; COG0395; Bacteria.
DR   HOGENOM; CLU_016047_1_2_11; -.
DR   InParanoid; Q9K489; -.
DR   OMA; CLAPFIH; -.
DR   PhylomeDB; Q9K489; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..276
FT                   /note="Diacetylchitobiose uptake system permease protein
FT                   DasC"
FT                   /id="PRO_0000447875"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          70..261
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   276 AA;  30681 MW;  60891D93D7A4BDB9 CRC64;
     MKRSLFGRVW PNVTAVVLFI GLVFPVYWMF ATAFKPTGDI ISENPVWFPT DITFEHFKTA
     TEADHFWTYV SNSLIVTVCA VVFSLVIALA GSFALARMRF KGRRGFIVGF MLAQMAPWEV
     MVIAIYMIVR DASMLNSLVP LTLFYMMMIL PFTILTLRGF VAAVPKELEE SAMVDGCTRA
     QAFRRVILPL LAPGLMSTSM FGFITAWNEL PLVLVVNKEA ESQTLPLWLT SFQTVFGDNW
     GATMAASSLF AIPILILFVY LQRKAVSGLT AGAVKG