ID   DASR_STRAW              Reviewed;         254 AA.
AC   Q82IW0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=HTH-type transcriptional repressor DasR;
GN   Name=dasR; OrderedLocusNames=SAV_3023;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- FUNCTION: Global regulator that is part of the nutrient-sensing system.
CC       In the absence of glucosamine 6-P (GlcN6P), represses the
CC       phosphotransferase system (PTS) specific for the uptake of N-
CC       acetylglucosamine (PTSNag), and genes involved in the metabolism of
CC       chitin, as well as several genes involved in development, thereby
CC       linking carbon availability to morphogenesis.
CC       {ECO:0000250|UniProtKB:Q9K492}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9K492}.
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DR   EMBL; BA000030; BAC70734.1; -; Genomic_DNA.
DR   RefSeq; WP_010984453.1; NZ_JZJK01000090.1.
DR   AlphaFoldDB; Q82IW0; -.
DR   SMR; Q82IW0; -.
DR   STRING; 227882.SAV_3023; -.
DR   EnsemblBacteria; BAC70734; BAC70734; SAVERM_3023.
DR   KEGG; sma:SAVERM_3023; -.
DR   eggNOG; COG2188; Bacteria.
DR   HOGENOM; CLU_063236_2_3_11; -.
DR   OMA; DRYKFVA; -.
DR   OrthoDB; 1775418at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..254
FT                   /note="HTH-type transcriptional repressor DasR"
FT                   /id="PRO_0000281407"
FT   DOMAIN          17..87
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        47..66
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   254 AA;  28226 MW;  1216B87E4CD50A90 CRC64;
     MSTDVSSAEN EGGAPIRTAR VPKYYRLKKH LLDMTETLPP GTPVPPERTL AAEFDTSRTT
     VRQALQELVV EGRLERIQGK GTFVAKPKVS QALQLTSYTE DMRAQGLEPT SQLLDIGYIT
     ADDTLAGLLD ITAGGRVLRI ERLRLASGEP MAIETTHLSA KRFPALRRSL VKYTSLYTAL
     AEVYDVRLAE AEETIETSLA TPREAGLLGT DVGLPMLMLS RHSLDKDGRP VEWVRSVYRG
     DRYKFVARLK RPQD