ID   DASR_STRGR              Reviewed;         253 AA.
AC   Q8VV01;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=HTH-type transcriptional repressor DasR;
GN   Name=dasR;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND EFFECT ON
RP   GLUCOSE-DEPENDENT MORPHOGENESIS.
RX   PubMed=11741848; DOI=10.1128/jb.184.1.91-103.2002;
RA   Seo J.-W., Ohnishi Y., Hirata A., Horinouchi S.;
RT   "ATP-binding cassette transport system involved in regulation of
RT   morphological differentiation in response to glucose in Streptomyces
RT   griseus.";
RL   J. Bacteriol. 184:91-103(2002).
CC   -!- FUNCTION: Global regulator that is part of the nutrient-sensing system.
CC       In the absence of glucosamine 6-P (GlcN6P), represses the
CC       phosphotransferase system (PTS) specific for the uptake of N-
CC       acetylglucosamine (PTSNag), and genes involved in the metabolism of
CC       chitin, as well as several genes involved in development, thereby
CC       linking carbon availability to morphogenesis (By similarity). Regulates
CC       the dasABC transport operon involved in glucose-related morphogenesis.
CC       Essential for development (PubMed:11741848).
CC       {ECO:0000250|UniProtKB:Q9K492, ECO:0000269|PubMed:11741848}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Actively expressed during vegetative growth.
CC       {ECO:0000269|PubMed:11741848}.
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DR   EMBL; AB061860; BAB79296.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8VV01; -.
DR   SMR; Q8VV01; -.
DR   PRIDE; Q8VV01; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..253
FT                   /note="HTH-type transcriptional repressor DasR"
FT                   /id="PRO_0000281409"
FT   DOMAIN          16..86
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        46..65
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   253 AA;  27946 MW;  24123D3E93523402 CRC64;
     MGAEGAVRGA RPVPVRAQRV PKYYRLKRHL LDMTDTLPPG TPVPPERTLA AEFDTSRTTV
     PQALQELVVE GRLERIQGKG TFVAKPKVSQ ALQLTSYTED MRAQGLEPTS QLLDIGYVTA
     DDTLAGLLDI STGGRVLRIE RLRLASGEPM AIETTHLSAK RFPALRRSLV KYTSLYTALA
     EVYDVRLAEA EETIETSLAT PREAGLLGTD VGLPMLMLSR HSVDGQGEPV EWVRSVYRGD
     RYKFVARLKR GTD