ID   DATIN_MYCTO             Reviewed;         273 AA.
AC   P9WMA8; L0T2D8; O53624; Q7DAH6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Dormancy associated translation inhibitor {ECO:0000250|UniProtKB:P9WMA9};
DE            Short=DATIN {ECO:0000250|UniProtKB:P9WMA9};
GN   OrderedLocusNames=MT0086;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- FUNCTION: Involved in translation regulation. Can also stimulate
CC       macrophages and peripheral blood mononuclear cells (PBMC) to secrete
CC       important cytokines that may be significant in granuloma formation and
CC       its maintenance. Increases secretion of IFN-gamma, TNF-alpha, IL-1 beta
CC       and IL-8 through human Toll-like receptor 2 (TLR2) signaling pathway.
CC       {ECO:0000250|UniProtKB:P9WMA9}.
CC   -!- SUBUNIT: Interacts with human TLR2. {ECO:0000250|UniProtKB:P9WMA9}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK44311.1; -; Genomic_DNA.
DR   PIR; H70849; H70849.
DR   RefSeq; WP_003400655.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMA8; -.
DR   EnsemblBacteria; AAK44311; AAK44311; MT0086.
DR   KEGG; mtc:MT0086; -.
DR   PATRIC; fig|83331.31.peg.91; -.
DR   HOGENOM; CLU_079045_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   Gene3D; 3.30.505.50; -; 2.
DR   InterPro; IPR032528; Ribosom_S30AE_C.
DR   InterPro; IPR038416; Ribosom_S30AE_C_sf.
DR   Pfam; PF16321; Ribosom_S30AE_C; 1.
PE   2: Evidence at transcript level;
KW   Virulence.
FT   CHAIN           1..273
FT                   /note="Dormancy associated translation inhibitor"
FT                   /id="PRO_0000427336"
SQ   SEQUENCE   273 AA;  29507 MW;  07F5BDC73A403E2B CRC64;
     MEPKRSRLVV CAPEPSHARE FPDVAVFSGG RANASQAERL ARAVGRVLAD RGVTGGARVR
     LTMANCADGP TLVQINLQVG DTPLRAQAAT AGIDDLRPAL IRLDRQIVRA SAQWCPRPWP
     DRPRRRLTTP AEALVTRRKP VVLRRATPLQ AIAAMDAMDY DVHLFTDAET GEDAVVYRAG
     PSGLRLARQH HVFPPGWSRC RAPAGPPVPL IVNSRPTPVL TEAAAVDRAR EHGLPFLFFT
     DQATGRGQLL YSRYDGNLGL ITPTGDGVAD GLA