DAU1_DAUCA
ID DAU1_DAUCA Reviewed; 154 AA.
AC O04298; O04296; O04297; Q39678; Q96407;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Major allergen Dau c 1;
DE AltName: Full=CR16;
DE AltName: Full=Pathogenesis-related protein Gea20;
DE AltName: Allergen=Dau c 1;
OS Daucus carota (Wild carrot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC Daucus; Daucus sect. Daucus.
OX NCBI_TaxID=4039;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Root;
RX PubMed=10336602; DOI=10.1046/j.1365-2222.1999.00529.x;
RA Hoffmann-Sommergruber K., O'Riordain G., Ahorn H., Ebner C.,
RA Da Camara Machado M.L., Puehringer H., Scheiner O., Breiteneder H.;
RT "Molecular characterization of Dau c 1, the Bet v 1 homologous protein from
RT carrot and its cross-reactivity with Bet v 1 and Api g 1.";
RL Clin. Exp. Allergy 29:840-847(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Root;
RX PubMed=9360325; DOI=10.1093/oxfordjournals.pcp.a029275;
RA Yamamoto M., Torikai S., Oeda K.;
RT "A major root protein of carrots with high homology to intracellular
RT pathogenesis-related (PR) proteins and pollen allergens.";
RL Plant Cell Physiol. 38:1080-1086(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Danvers Half-long;
RX PubMed=8938424; DOI=10.1104/pp.112.3.1365;
RA Lin X., Hwang G.J., Zimmerman J.L.;
RT "Isolation and characterization of a diverse set of genes from carrot
RT somatic embryos.";
RL Plant Physiol. 112:1365-1374(1996).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS), AND SUBUNIT.
RX PubMed=19923716; DOI=10.1107/s0907444909034854;
RA Markovic-Housley Z., Basle A., Padavattan S., Maderegger B., Schirmer T.,
RA Hoffmann-Sommergruber K.;
RT "Structure of the major carrot allergen Dau c 1.";
RL Acta Crystallogr. D 65:1206-1212(2009).
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:19923716}.
CC -!- ALLERGEN: Causes an allergic reaction in human.
CC -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB01092.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Z84376; CAB06416.1; -; mRNA.
DR EMBL; Z81361; CAB03715.1; -; mRNA.
DR EMBL; Z81362; CAB03716.1; -; mRNA.
DR EMBL; D88388; BAA13604.1; -; mRNA.
DR EMBL; U47087; AAB01092.1; ALT_INIT; mRNA.
DR PIR; T14322; T14322.
DR PIR; T14325; T14325.
DR PIR; T14326; T14326.
DR PIR; T14356; T14356.
DR PDB; 2WQL; X-ray; 2.70 A; A/B/C/D=1-154.
DR PDBsum; 2WQL; -.
DR AlphaFoldDB; O04298; -.
DR SMR; O04298; -.
DR Allergome; 287; Dau c 1.
DR Allergome; 288; Dau c 1.0101.
DR Allergome; 289; Dau c 1.0102.
DR Allergome; 290; Dau c 1.0103.
DR Allergome; 291; Dau c 1.0104.
DR Allergome; 292; Dau c 1.0105.
DR EvolutionaryTrace; O04298; -.
DR GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR000916; Bet_v_I/MLP.
DR InterPro; IPR024949; Bet_v_I_allergen.
DR InterPro; IPR023393; START-like_dom_sf.
DR Pfam; PF00407; Bet_v_1; 1.
DR PRINTS; PR00634; BETALLERGEN.
DR SMART; SM01037; Bet_v_1; 1.
DR PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Allergen; Pathogenesis-related protein; Plant defense.
FT CHAIN 1..154
FT /note="Major allergen Dau c 1"
FT /id="PRO_0000154188"
FT VARIANT 36
FT /note="P -> T (in Dau C 1.2)"
FT VARIANT 43
FT /note="E -> D (in Dau C 1.3 and CR16/Gea20)"
FT VARIANT 66
FT /note="S -> T (in Dau C 1.2)"
FT VARIANT 80
FT /note="T -> S (in Dau C 1.2)"
FT VARIANT 93
FT /note="G -> E (in CR16/Gea20)"
FT VARIANT 102
FT /note="L -> M (in Dau C 1.2 and CR16/Gea20)"
FT VARIANT 138
FT /note="A -> E (in Dau C 1.3)"
FT STRAND 5..14
FT /evidence="ECO:0007829|PDB:2WQL"
FT HELIX 16..23
FT /evidence="ECO:0007829|PDB:2WQL"
FT TURN 24..26
FT /evidence="ECO:0007829|PDB:2WQL"
FT HELIX 27..34
FT /evidence="ECO:0007829|PDB:2WQL"
FT TURN 36..38
FT /evidence="ECO:0007829|PDB:2WQL"
FT STRAND 40..49
FT /evidence="ECO:0007829|PDB:2WQL"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:2WQL"
FT STRAND 66..75
FT /evidence="ECO:0007829|PDB:2WQL"
FT TURN 76..79
FT /evidence="ECO:0007829|PDB:2WQL"
FT STRAND 80..88
FT /evidence="ECO:0007829|PDB:2WQL"
FT HELIX 89..91
FT /evidence="ECO:0007829|PDB:2WQL"
FT TURN 92..94
FT /evidence="ECO:0007829|PDB:2WQL"
FT STRAND 95..106
FT /evidence="ECO:0007829|PDB:2WQL"
FT STRAND 112..123
FT /evidence="ECO:0007829|PDB:2WQL"
FT HELIX 130..153
FT /evidence="ECO:0007829|PDB:2WQL"
SQ SEQUENCE 154 AA; 16049 MW; 3C5AB57AE671DE82 CRC64;
MGAQSHSLEI TSSVSAEKIF SGIVLDVDTV IPKAAPGAYK SVEVKGDGGA GTVRIITLPE
GSPITSMTVR TDAVNKEALT YDSTVIDGDI LLGFIESIET HLVVVPTADG GSITKTTAIF
HTKGDAVVPE ENIKFADAQN TALFKAIEAY LIAN
