ID   DAW1_RAT                Reviewed;         415 AA.
AC   Q5BK30;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Dynein assembly factor with WDR repeat domains 1;
DE   AltName: Full=Outer row dynein assembly protein 16 homolog;
DE   AltName: Full=WD repeat-containing protein 69;
GN   Name=Daw1; Synonyms=Wdr69;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in axonemal outer row dynein assembly.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR69 family. {ECO:0000305}.
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DR   EMBL; BC091226; AAH91226.1; -; mRNA.
DR   RefSeq; NP_001020196.1; NM_001025025.1.
DR   AlphaFoldDB; Q5BK30; -.
DR   SMR; Q5BK30; -.
DR   BioGRID; 264090; 1.
DR   STRING; 10116.ENSRNOP00000059421; -.
DR   PhosphoSitePlus; Q5BK30; -.
DR   PaxDb; Q5BK30; -.
DR   GeneID; 363267; -.
DR   KEGG; rno:363267; -.
DR   UCSC; RGD:1561436; rat.
DR   CTD; 164781; -.
DR   RGD; 1561436; Daw1.
DR   VEuPathDB; HostDB:ENSRNOG00000016247; -.
DR   eggNOG; KOG0272; Eukaryota.
DR   HOGENOM; CLU_000288_57_33_1; -.
DR   InParanoid; Q5BK30; -.
DR   OMA; TGQCSQV; -.
DR   OrthoDB; 872177at2759; -.
DR   PhylomeDB; Q5BK30; -.
DR   TreeFam; TF323481; -.
DR   PRO; PR:Q5BK30; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000016247; Expressed in testis and 6 other tissues.
DR   ExpressionAtlas; Q5BK30; baseline.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR   GO; GO:0090660; P:cerebrospinal fluid circulation; ISO:RGD.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR   GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:RGD.
DR   GO; GO:0051649; P:establishment of localization in cell; ISO:RGD.
DR   GO; GO:0007507; P:heart development; ISO:RGD.
DR   GO; GO:0036158; P:outer dynein arm assembly; ISO:RGD.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 4.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 8.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 8.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..415
FT                   /note="Dynein assembly factor with WDR repeat domains 1"
FT                   /id="PRO_0000242656"
FT   REPEAT          90..129
FT                   /note="WD 1"
FT   REPEAT          132..174
FT                   /note="WD 2"
FT   REPEAT          175..214
FT                   /note="WD 3"
FT   REPEAT          217..256
FT                   /note="WD 4"
FT   REPEAT          259..298
FT                   /note="WD 5"
FT   REPEAT          301..340
FT                   /note="WD 6"
FT   REPEAT          343..384
FT                   /note="WD 7"
FT   REPEAT          386..415
FT                   /note="WD 8"
SQ   SEQUENCE   415 AA;  45859 MW;  0F96FF1CD75275B5 CRC64;
     MKLKSLLLRY YPPGIMLEYE KGGELKTKSI DLLELSPSTD VNTLVGEIQK VEPLITASRT
     KQVRLLVQRL QEKLRQHCDH NFYLFKVLRA HILPLTNVAL NKAGSCFITG SYDRTCKVWD
     TASGEELHTL EGHRNVVYAI AFNNPYGDKI ATGSFDKTCK LWSAETGKCY HTFRGHTAEI
     VCLSFNPQST VVATGSMDTT AKLWDIQSGE EVVTLTGHLA EIISLSFDTS GDRIITGSFD
     HTVVVWDAST GRKVHTLIGH CAEISSALFS WDCSLILTGS MDKTCMLWDA TSGKCVATLT
     GHDDEILDSC FDYTGKLIAT ASADGTARVY NATTRKCITK LEGHEGEISK ISFNPQGNRL
     LTGSSDKTAR IWDVQTGQCL QVLEGHTDEI FSCAFNYKGN IVITGSKDNS CRIWR