DAZ1_CAEEL
ID DAZ1_CAEEL Reviewed; 499 AA.
AC Q20870; Q9U5G2;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=DAZ protein 1;
GN Name=daz-1; ORFNames=F56D1.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=Bristol N2;
RX PubMed=10662646; DOI=10.1242/dev.127.5.1069;
RA Karashima T., Sugimoto A., Yamamoto M.;
RT "Caenorhabditis elegans homologue of the human azoospermia factor DAZ is
RT required for oogenesis but not for spermatogenesis.";
RL Development 127:1069-1079(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: RNA-binding protein that plays a central role in oogenesis,
CC but not for spermatogenesis. Required for meiotic entry and germline
CC differentiation, at the pachytene stage of meiosis I of female germline
CC regardless of the sex of the soma. May act by regulating translation of
CC specific mRNAs, possibly by binding to their 3'-UTR.
CC {ECO:0000269|PubMed:10662646}.
CC -!- TISSUE SPECIFICITY: Germline specific. More strongly expressed during
CC oogenesis than during spermatogenesis. During the larval stages, it is
CC more abundant at the distal region than the proximal region of the
CC gonad. In young adult hermaphrodites, it is expressed at a very low
CC level in the distal mitotic region of the gonad, and begins to
CC accumulate in the meiotic transition zone. Highly expressed in the
CC proximal pachytene region. Not expressed in mature oocytes. Not
CC expressed in the spermatheca. Weakly or not expressed in the germline
CC of adult males. {ECO:0000269|PubMed:10662646}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the germline from the L2 stage larva.
CC {ECO:0000269|PubMed:10662646}.
CC -!- SIMILARITY: Belongs to the RRM DAZ family. {ECO:0000255|PROSITE-
CC ProRule:PRU01238}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CCD68962.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB025253; BAA88577.1; -; mRNA.
DR EMBL; FO081078; CCD68962.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_495036.3; NM_062635.4.
DR AlphaFoldDB; Q20870; -.
DR SMR; Q20870; -.
DR BioGRID; 39275; 1.
DR STRING; 6239.F56D1.7; -.
DR iPTMnet; Q20870; -.
DR EPD; Q20870; -.
DR PaxDb; Q20870; -.
DR PeptideAtlas; Q20870; -.
DR EnsemblMetazoa; F56D1.7.1; F56D1.7.1; WBGene00000935.
DR GeneID; 173931; -.
DR KEGG; cel:CELE_F56D1.7; -.
DR UCSC; F56D1.7; c. elegans.
DR CTD; 173931; -.
DR WormBase; F56D1.7; CE27175; WBGene00000935; daz-1.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00530000063480; -.
DR HOGENOM; CLU_504562_0_0_1; -.
DR InParanoid; Q20870; -.
DR OrthoDB; 1610446at2759; -.
DR PRO; PR:Q20870; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000935; Expressed in germ line (C elegans) and 5 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IBA:GO_Central.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0045948; P:positive regulation of translational initiation; IBA:GO_Central.
DR CDD; cd12412; RRM_DAZL_BOULE; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR037366; BOULE/DAZ.
DR InterPro; IPR034988; DAZ_BOULE_RRM.
DR InterPro; IPR043628; DAZ_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR11176; PTHR11176; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS51890; DAZ; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Oogenesis; Reference proteome;
KW RNA-binding; Translation regulation.
FT CHAIN 1..499
FT /note="DAZ protein 1"
FT /id="PRO_0000081564"
FT DOMAIN 66..144
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 214..236
FT /note="DAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01238"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 56153 MW; 8A3458C9152A89C6 CRC64;
MMSPPLRYQK DQQNQQHQQN QSQQAAHQMV SFMPQTPTSL PSTPIQLYPT GAAALIPAPP
TYELIPNRIF VGGFPTSTTE TELREHFEKF FAVKDVKMVK SLDGQSKGYG FITFETEDQA
EEIRKLTPKQ LEFRSRKLNL GPAIRKINSN SFQPSYAIAT PSQLVAASPG PFSYAIPASP
SPYSGYSYPA SPQMFVYPPL RSQDQSRQQS EQQTTPQNSP TNLQHQQSPQ VFFGGDQDPI
RSYASAVAGV EKSEVSPEKH ESVSPQPLLP NQNVLNTQYS QGQQQWNSNV QQQQQQQMDS
NNGGPYYNEN YSQGYTRPHP YQQFAQSGVY MNSQGMYHSS YSYMTPPLAP GQYPQMMSAP
YWQQQQQHHQ SHAYAGYNPA YNNWVGPSGD MNQFKQNPSN YFYQNYPGNF SQQHTMGNNE
NTFSLPLQAP RQGKKSRKPS ECQDKKTKSP IKGARTERPS SSASTPDAKY QKNHRYPVHL
SPLSASLQSL AISSPTKNN
